Over the past decades, the number of patients with dry eye disease (DED) has increased
dramatically. The incidence of DED is higher in Asia than in Europe and North America …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by
symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully …

Dry eye is a common ocular surface inflammatory disease that significantly affects quality of
life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular …

Publication of the DEWS report in 2007 established the state of the science of dry eye
disease (DED). Since that time, new evidence suggests that a rethinking of traditional …

Purpose: The purpose of this article is to review the evidence for the hypothesis that the core
mechanism of dry eye disease (DED) is inflammation, including evidence from recent basic …

The etiology of dry eye disease (DED) is complex and not yet fully understood, but the
disease is now recognized as being associated with ocular surface inflammation. The latest …

Homeostasis of the lacrimal functional unit is needed to ensure a well-regulated ocular
immune response comprising innate and adaptive phases. When the ocular immune system …

The tear film, lacrimal glands, corneal and conjunctival epithelia and Meibomian glands
work together as a lacrimal functional unit (LFU) to preserve the integrity and function of the …

Ocular allergy (OA) and dry eye disease (DED) are the most common ocular surface
disorders with a potential severe impact on the patient's quality of life. OA and DED may …