The effects of aging in the hippocampus and cognitive decline
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …
social impairments. One structure of particular interest when considering aging and …
[HTML][HTML] Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise
Of wide interest for health is the relation existing between depression, a very common
psychological illness, accompanied by anxiety and reduced ability to concentrate, and adult …
psychological illness, accompanied by anxiety and reduced ability to concentrate, and adult …
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
Aging drives cognitive and regenerative impairments in the adult brain, increasing
susceptibility to neurodegenerative disorders in healthy individuals,,,. Experiments using …
susceptibility to neurodegenerative disorders in healthy individuals,,,. Experiments using …
Recalibrating the relevance of adult neurogenesis
JS Snyder - Trends in neurosciences, 2019 - cell.com
Conflicting reports about whether adult hippocampal neurogenesis occurs in humans raise
questions about its significance for human health and the relevance of animal models …
questions about its significance for human health and the relevance of animal models …
[HTML][HTML] Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction
Traumatic brain injury (TBI) leads to lasting brain dysfunction with chronic
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …
Antidepressants increase neural progenitor cells in the human hippocampus
Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs)
increase neurogenesis in the dentate gyrus (DG) of rodents and nonhuman primates. We …
increase neurogenesis in the dentate gyrus (DG) of rodents and nonhuman primates. We …
Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties
Grafting of neural stem cells (NSCs) derived from human induced pluripotent stem cells
(hiPSCs) has shown promise for brain repair after injury or disease, but safety issues have …
(hiPSCs) has shown promise for brain repair after injury or disease, but safety issues have …
Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression
BACKGROUND: Adult neurogenesis is coupled to angiogenesis in neurogenic niches in the
dentate gyrus (DG) and increased by antidepressants in rodents. We hypothesized that, in …
dentate gyrus (DG) and increased by antidepressants in rodents. We hypothesized that, in …
Microglia: multitasking specialists of the brain
AM Casano, F Peri - Developmental cell, 2015 - cell.com
Microglia are macrophages that colonize the brain during development to establish a
resident population of professional phagocytes that protect against invading pathogens and …
resident population of professional phagocytes that protect against invading pathogens and …
Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats
AD Bachstetter, JM Morganti, J Jernberg, A Schlunk… - Neurobiology of …, 2011 - Elsevier
Microglia have neuroprotective capacities, yet chronic activation can promote neurotoxic
inflammation. Neuronal fractalkine (FKN), acting on CX3CR1, has been shown to suppress …
inflammation. Neuronal fractalkine (FKN), acting on CX3CR1, has been shown to suppress …