HIV latency in myeloid cells: challenges for a cure

A Chitrakar, M Sanz, SB Maggirwar, N Soriano-Sarabia - Pathogens, 2022 - mdpi.com
The use of antiretroviral therapy (ART) for Human Immunodeficiency Virus (HIV) treatment
has been highly successful in controlling plasma viremia to undetectable levels. However, a …

Genomic factors and therapeutic approaches in HIV-associated neurocognitive disorders: a comprehensive review

A Borrajo, D Pérez-Rodríguez… - International Journal of …, 2023 - mdpi.com
HIV-associated neurocognitive disorders (HANDs) still persist despite improved life
expectancy, reduced viral loads, and decreased infection severity. The number of patients …

Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection

HS Fox, M Niu, BM Morsey, BG Lamberty… - Frontiers in …, 2022 - frontiersin.org
The twin pandemics of opioid abuse and HIV infection can have devastating effects on
physiological systems, including on the brain. Our previous work found that morphine …

Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells

SBH Gumbs, AJ Stam, T Mudrikova, PJ Schipper… - Journal of …, 2024 - Springer
Despite antiretroviral therapy (ART), HIV persistence in the central nervous system (CNS)
continues to cause a range of cognitive impairments in people living with HIV (PLWH). Upon …

Cognitive impairment and neurocognitive profiles among people living with HIV and HIV-negative individuals older over 50 years: a comparison of IHDS, MMSE and …

P Chen, X Xin, S Xiao, H Liu, X Liu, N He… - Journal of …, 2024 - Springer
We aimed to examine the l differences in the assessment of neurocognitive impairment
(NCI) using cognitive screening tools between PLWH and HIV-negative individuals and …

[HTML][HTML] Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain

J Pla-Tenorio, AM Roig, PA García-Cesaní… - Current Research in …, 2023 - Elsevier
The roles of astrocytes as reservoirs and producers of a subset of viral proteins in the HIV
infected brain have been studied extensively as a key to understanding HIV-associated …

HIV-Bidirectional Encoder Representations From Transformers: A Set of Pretrained Transformers for Accelerating HIV Deep Learning Tasks

W Dampier, RW Link, JP Earl, M Collins… - Frontiers in …, 2022 - frontiersin.org
The human immunodeficiency virus type 1 (HIV-1) is a global health threat that is
characterized by extensive genetic diversity both within and between patients, rapid …

Utilizing Nanodiamond for Antiretroviral Drug Delivery to HIV Infected Microglial Cells

E Owusu - 2024 - search.proquest.com
Combination antiretroviral therapy (cART) is widely used to treat HIV infection, but it fails to
eradicate viral reservoirs, such as microglia in the brain, leading to HIV-associated …

Genomic factors and therapeutic approaches in HIV-associated neurocognitive disorders: a comprehensive review

A Borrajo López, D Pérez-Rodríguez… - 2023 - docta.ucm.es
HIV-associated neurocognitive disorders (HANDs) still persist despite improved life
expectancy, reduced viral loads, and decreased infection severity. The number of patients …

[引用][C] Characterization of HIV variants from paired CSF and Plasma samples in primary microglia and CD4+ T cells

SBH Gumbs, AJ Stam, T Mudrikova, PJ Schipper… - … AS A VIRAL RESERVOIR FOR HIV