Background: Various pieces of evidence have shown that people who consume foods rich in
polyphenolic and flavonoids compounds have a lower incidence of inflammatory …

Polyphenols are a wide class of natural substances, pleiotropic molecules capable of
modulating several processes, involved in the humoral and cellular immune response. The …

Background Overexpression of membranous CD154 in T lymphocytes has been found
previously in systemic lupus erythematosus (SLE). Because hydroxychloroquine (HCQ) has …

Purpose Recently, therapeutic effects of 6-methoxyflavone (6MF) have been reported.
However, the use of 6MF is limited due to its poor water solubility. The low aqueous …

Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose limiting side-effect of
several commonly used chemotherapeutic agents (such as cisplatin) that profoundly impairs …

Background Microglia-related neuroinflammation is associated with a variety of
neurodegenerative diseases. Flavonoids have demonstrated different pharmacological …

Atopic dermatitis (AD) is a chronic cutaneous disease with a complex underlying
mechanism, and it cannot be completely cured. Thus, most treatment strategies for AD aim at …

Naïve CD4+ T cells differentiate into diverse subsets of effector cells and perform various
homeostatic and immune functions. The differentiation and maintenance of these different …

Neuropathy is a disturbance of function or a pathological change in nerves causing poor
health and quality of life. A proportion of chronic pain patients in the community suffer …

Purpose Chronic ethanol exposure causes neurotoxicity and long-term learning and
memory impairment along with hippocampal and frontal cortical dysfunction. Flavonoids …