Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as
prototypes for growth factor and receptor tyrosine kinase function for more than 25 years …

Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility
by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor …

Ras (p21 ras) interacts directly with the catalytic subunit of phosphatidylinositol-3-OH kinase
in a GTP-dependent manner through the Ras effector site. In vivo, dominant negative Ras …

Background: The actin-related proteins Arp2 and Arp3 are part of a seven-protein complex
which is localized in the lamellipodia of a variety of cell types, and in actin-rich spots of …

Signaling by tyrosine kinase receptors is mediated by selective interactions between
individual Src homology 2 (SH2) domains of cytoplasmic effectors and specific …

Nerve growth factor (NGF) induces both differentiation and survival of neurons by binding to
the Trk receptor protein tyrosine kinase. Although Ras is required for differentiation, it was …

Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling
receptor for a number of cell types, including hematopoietic stem cells, mast cells …

We analyzed the binding site (s) for Grb2 on the epidermal growth factor (EGF) receptor
(EGFR), using cell lines overexpressing EGFRs containing various point and deletion …

The transduction of a signal is a change in form of the signal as it is passed from one carrier
to another. The root" duce" means" to lead" in Latin; thus, a signal is led through a cell by …

Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to
specific phosphotyrosine (phospho-Tyr)-containing sequences. We recently developed a …