The maternal diet during pregnancy is a key determinant of offspring health. Early studies
have linked poor maternal nutrition during gestation with a propensity for the development of …

Cytosine base modifications in mammals underwent a recent expansion with the addition of
several naturally occurring further modifications of methylcytosine in the last years. This …

Ten-eleven translocation (TET) family of enzymes are non-heme Fe (II)-and 2-oxoglutarate
(2OG)-dependent oxygenases that perform oxidation of the methyl group of the 5 …

Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for
mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosine (5hmC), 5 …

Ten-eleven translocation (TET) enzymes catalyze stepwise oxidation of 5-methylcytosine
(mC) to yield 5-hydroxymethylcytosine (hmC) and the rarer bases 5-formylcytosine (fC) and …

In mammalian genomes, cytosine methylation occurs predominantly at CG (or CpG)
dinucleotide contexts. As part of dynamic epigenetic regulation, 5-methylcytosine (mC) can …

Arginine methylation is an important mechanism of epigenetic regulation. Some Fe (II) and 2‐
oxoglutarate dependent Jumonji‐C (JmjC) Nϵ‐methyl lysine histone demethylases also …

Biocatalytic C–H oxidation reactions are of important synthetic utility, provide a sustainable
route for selective synthesis of important organic molecules, and are an integral part of …

Ten-eleven translocation 2 (TET2) is an Fe/α-ketoglutarate (α-KG) dependent enzyme that
dealkylates 5-methylcytosine (5mC). The reaction mechanism involves a series of three …

As the predominant epigenetic markers, methyl-modifying enzymes-catalyzed methylation
modification widely participates in the regulation of cellular functions, and the dysregulation …