[HTML][HTML] Exploring molecular mechanisms and biomarkers in COPD: an overview of current advancements and perspectives
CL Li, SF Liu - International Journal of Molecular Sciences, 2024 - mdpi.com
Chronic obstructive pulmonary disease (COPD) plays a significant role in global morbidity
and mortality rates, typified by progressive airflow restriction and lingering respiratory …
and mortality rates, typified by progressive airflow restriction and lingering respiratory …
PDGFRα-positive cell-derived TIMP-1 modulates adaptive immune responses to influenza A viral infection
TIMP-1 (tissue inhibitor of metalloproteinases-1) is a physiologic inhibitor of the matrix
metalloproteinases (MMPs), but little is known about the role of TIMP-1 in regulating the …
metalloproteinases (MMPs), but little is known about the role of TIMP-1 in regulating the …
[HTML][HTML] Biomarkers in idiopathic pulmonary fibrosis: Current insight and future direction
Z Zheng, F Peng, Y Zhou - Chinese Medical Journal Pulmonary and Critical …, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease with
a dismal prognosis. Early diagnosis, accurate prognosis, and personalized therapeutic …
a dismal prognosis. Early diagnosis, accurate prognosis, and personalized therapeutic …
Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2
Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed
as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of …
as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of …
Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis
C Zeng, H Yue, C Wang, X Ju, T Wang, X Fu… - Journal of Translational …, 2024 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic and lethal lung disorder for
which effective treatments remain limited. Recent investigations revealed a potential link …
which effective treatments remain limited. Recent investigations revealed a potential link …
The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection
M Negaresh, E Safarzadeh, N Fouladi, S Matin… - BMC …, 2023 - Springer
Background Helicobacter pylori (H. pylori) is one of the leading causes of peptic ulcers, and
its treatment is a worldwide challenge. Matrix metalloproteinases and their inhibitors …
its treatment is a worldwide challenge. Matrix metalloproteinases and their inhibitors …
Estrogen‐dependent gene regulation: Molecular basis of TIMP‐1 as a sex‐specific biomarker for acute lung injury
Increased circulating tissue inhibitor of metalloproteinases‐1 (TIMP‐1) levels have been
observed in patients with acute lung injury (ALI). However, the sex‐specific regulation of …
observed in patients with acute lung injury (ALI). However, the sex‐specific regulation of …
[HTML][HTML] Metformin alleviates benzo [a] pyrene-induced alveolar injury by inhibiting necroptosis and protecting AT2 cells
MY Quan, X Yan, W Miao, X Li, J Li, L Yang… - Ecotoxicology and …, 2024 - Elsevier
Exposure to benzo [a] pyrene (B [a] P) has been linked to lung injury and carcinogenesis.
Airway epithelial cells express the B [a] P receptor AHR, so B [a] P is considered to mainly …
Airway epithelial cells express the B [a] P receptor AHR, so B [a] P is considered to mainly …
Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of …
X Yuan, X Qin, K Takemoto, J Zhao… - Annals of the …, 2024 - ard.bmj.com
Objective We assessed the role of a systemic lupus erythematosus causal hypofunctional
variant, neutrophil cytosolic factor 1 (NCF1)-p. Arg90His (p. R90H) substitution, in systemic …
variant, neutrophil cytosolic factor 1 (NCF1)-p. Arg90His (p. R90H) substitution, in systemic …