PI3K/AKT signaling pathway and cancer: an updated review
Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …
therapies to the genetic status of individual tumors is proving to be a daunting task for …
The emerging mechanisms of isoform-specific PI3K signalling
B Vanhaesebroeck, J Guillermet-Guibert… - … reviews Molecular cell …, 2010 - nature.com
Abstract Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal
transduction pathways and affect many biological functions. A further level of complexity …
transduction pathways and affect many biological functions. A further level of complexity …
Classes of phosphoinositide 3-kinases at a glance
S Jean, AA Kiger - Journal of cell science, 2014 - journals.biologists.com
ABSTRACT The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of
cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially …
cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially …
[HTML][HTML] PI3K-AKT-mTOR and NFκB pathways in ovarian cancer: implications for targeted therapeutics
Ovarian cancer is the most lethal gynecologic malignancy in the United States, with an
estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that …
estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that …
Class II PI3K functions in cell biology and disease
The phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate
inositol phospholipids, thereby controlling membrane lipid composition and regulating a …
inositol phospholipids, thereby controlling membrane lipid composition and regulating a …
Mammalian phosphoinositide kinases and phosphatases
T Sasaki, S Takasuga, J Sasaki, S Kofuji… - Progress in lipid …, 2009 - Elsevier
Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …
Regulation and cellular functions of class II phosphoinositide 3-kinases
M Falasca, T Maffucci - Biochemical Journal, 2012 - portlandpress.com
Class II isoforms of PI3K (phosphoinositide 3-kinase) are still the least investigated and
characterized of all PI3Ks. In the last few years, an increased interest in these enzymes has …
characterized of all PI3Ks. In the last few years, an increased interest in these enzymes has …
Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies
The phosphoinositide 3-kinase/mammalian target of rapamycin/protein kinase B
(PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms in a wide …
(PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms in a wide …
[PDF][PDF] Local synthesis of the phosphatidylinositol-3, 4-bisphosphate lipid drives focal adhesion turnover
Y Posor, C Kampyli, B Bilanges, S Ganguli, PA Koch… - Developmental cell, 2022 - cell.com
Focal adhesions are multifunctional organelles that couple cell-matrix adhesion to
cytoskeletal force transmission and signaling and to steer cell migration and collective cell …
cytoskeletal force transmission and signaling and to steer cell migration and collective cell …
The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics
Phosphatidylinositol (PI) 4, 5-bisphosphate (PI (4, 5) P2) and its phosphorylated product PI
3, 4, 5-triphosphate (PI (3, 4, 5) P3) are two major phosphoinositides concentrated at the …
3, 4, 5-triphosphate (PI (3, 4, 5) P3) are two major phosphoinositides concentrated at the …