Abstract Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity
and cancers (eg lung and bladder cancer), since it is responsible for metabolizing a number …

Aromatic amines are an important class of human carcinogens found ubiquitously in our
environment. It is estimated that 1 in 8 of all known or suspected human carcinogens is or …

Many chemical carcinogens require metabolic activation via xenobiotic-metabolizing
enzymes in order to exert their genotoxic effects. Evidence from numerous in-vitro studies …

Aminobiphenyl (4-ABP) is a human bladder cancer carcinogen found in the manufacture of
azo dyes and the composition of cigarette smoke in the environment. To determine whether …

Brassica vegetables may modulate cancer risk by regulation of xenobiotic metabolizing
enzymes (XMEs). In a randomized crossover study, the effect of kale consumption on …

The cytochrome P450 (CYP) enzyme superfamily is the most important enzyme system for
phase I biotransformation. For toxico-and pharmacokinetic studies, use of liver-based …

The incidence of liver cancer is higher in men than in women. This sex difference is also
observed in murine tumor induction models that result in the appearance of liver tumors in …

Chemicals in commerce or under development must be assessed for genotoxicity;
assessment is generally conducted using validated assays (eg Tk mouse lymphoma assay) …

TP53 harbors somatic mutations in more than half of human tumors with some showing
characteristic mutation spectra that have been linked to environmental exposures. In bladder …

Genetically modified mouse models serve as useful in vivo tools to confirm or refute the
involvement of specific drug-metabolizing enzymes, including the arylamine N …