Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of …

Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …

Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Although proteins are translated on cytoplasmic ribosomes, many of these proteins play
essential roles in the nucleus, mediating key cellular processes including but not limited to …

Bidirectional transport of macromolecules across the nuclear envelope is a hallmark of
eukaryotic cells, in which the genetic material is compartmentalized inside the nucleus. The …

Recent insights into the regulation of the androgen receptor (AR) activity led to novel
therapeutic targeting of AR function in prostate cancer patients. Docetaxel is an approved …

Mitosis-specific agents have, to date, not been clinically successful. By contrast, microtubule-
targeting agents (MTAs) have a long record of success, usually attributed to the induction of …

Steroid hormone receptors (SHRs) are notorious intracellular travellers, transiting among
different cellular compartments as they mature, are subjected to regulation and exert their …

Cellular functions are dictated by protein content and activity. There are numerous strategies
to regulate proteins varying from modulating gene expression to post‐translational …

Macromolecules and supramolecular complexes are frequently required to enter and exit
the nucleus during normal cell function, but access is restricted and exchange to and from …