Dissecting molecular mechanisms underlying the inhibition of β-glucuronidase by alkaloids from Hibiscus trionum: Integrating in vitro and in silico perspectives
EM Kamel, FFA Alkhayl, HA Alqhtani… - Computers in biology …, 2024 - Elsevier
Abstract β-Glucuronidase, a crucial enzyme in drug metabolism and detoxification,
represents a promising target for therapeutic intervention due to its potential to modulate …
represents a promising target for therapeutic intervention due to its potential to modulate …
Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and …
X Bai, X Zhao, K Liu, X Yang, Q He, Y Gao, W Li… - International Journal of …, 2024 - mdpi.com
Recently, studies have reported a correlation that individuals with diabetes show an
increased risk of developing Alzheimer's disease (AD). Mulberry leaves, serving as both a …
increased risk of developing Alzheimer's disease (AD). Mulberry leaves, serving as both a …
Design of Vif-Derived Peptide Inhibitors with Anti-HIV-1 Activity by Interrupting Vif-CBFβ Interaction
Y Gai, S Duan, S Wang, K Liu, X Yu, C Yang, G Li… - Viruses, 2024 - mdpi.com
One of the major functions of the accessory protein Vif of human immunodeficiency virus
type 1 (HIV-1) is to induce the degradation of APOBEC3 (A3) family proteins by recruiting a …
type 1 (HIV-1) is to induce the degradation of APOBEC3 (A3) family proteins by recruiting a …
[HTML][HTML] Computational Insights into Reproductive Toxicity: Clustering, Mechanism Analysis, and Predictive Models
H Cui, Q He, W Li, Y Duan, W Han - International Journal of Molecular …, 2024 - mdpi.com
Reproductive toxicity poses significant risks to fertility and progeny health, making its
identification in pharmaceutical compounds crucial. In this study, we conducted a …
identification in pharmaceutical compounds crucial. In this study, we conducted a …
Integrating Computational and Experimental Methods to Identify Novel Sweet Peptides from Egg and Soy Proteins
J Su, K Liu, H Cui, T Shen, X Fu, W Han - International Journal of …, 2024 - mdpi.com
Sweetness in food delivers a delightful sensory experience, underscoring the crucial role of
sweeteners in the food industry. However, the widespread use of sweeteners has sparked …
sweeteners in the food industry. However, the widespread use of sweeteners has sparked …