Targeting TGF-β mediated SMAD signaling for the prevention of fibrosis
KL Walton, KE Johnson, CA Harrison - Frontiers in pharmacology, 2017 - frontiersin.org
Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and
degradation. Excessive ECM deposition results in scarring and thickening of the affected …
degradation. Excessive ECM deposition results in scarring and thickening of the affected …
Remodelling the extracellular matrix in development and disease
The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and
continuously undergoes controlled remodelling. This process involves quantitative and …
continuously undergoes controlled remodelling. This process involves quantitative and …
Overview of the mechanisms that may contribute to the non-redundant activities of interferon-inducible CXC chemokine receptor 3 ligands
M Metzemaekers, V Vanheule, R Janssens… - Frontiers in …, 2018 - frontiersin.org
The inflammatory chemokines CXCL9, CXCL10, and CXCL11 are predominantly induced
by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC chemokine …
by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC chemokine …
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for …
F Bachelerie, A Ben-Baruch, AM Burkhardt… - Pharmacological …, 2014 - ASPET
Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
[HTML][HTML] A microRNA-29 mimic (Remlarsen) represses extracellular matrix expression and fibroplasia in the skin
CL Gallant-Behm, J Piper, JM Lynch, AG Seto… - Journal of Investigative …, 2019 - Elsevier
MicroRNA-29 (miR-29) negatively regulates fibrosis and is downregulated in multiple fibrotic
organs and tissues, including in the skin. miR-29 mimics prevent pulmonary fibrosis in …
organs and tissues, including in the skin. miR-29 mimics prevent pulmonary fibrosis in …
[HTML][HTML] Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
The discovery of the myofibroblast has opened new perspectives for the comprehension of
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …
the biological mechanisms involved in wound healing and fibrotic diseases. In recent years …
Heparan sulfate proteoglycans
S Sarrazin, WC Lamanna… - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have …
where they interact with a plethora of ligands. Over the last decade, new insights have …
The myofibroblast matrix: implications for tissue repair and fibrosis
Myofibroblasts, and the extracellular matrix (ECM) in which they reside, are critical
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …
Integrating mechanisms of pulmonary fibrosis
TA Wynn - Journal of Experimental Medicine, 2011 - rupress.org
Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …
CXCR3 in T cell function
JR Groom, AD Luster - Experimental cell research, 2011 - Elsevier
CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …