Chronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic
COPD and allergic rhinitis are a global health concern. Despite the coexistence of these …

Asthma varies considerably across the life course. Childhood asthma is known for its overall
high prevalence with a male predominance prior to puberty, common remission, and rare …

Although asthma has been considered as a single disease for years, recent studies have
increasingly focused on its heterogeneity. The characterization of this heterogeneity has …

Interleukins (IL)-4 and-13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-
4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and …

Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

In this consensus document we summarize the current knowledge on major asthma, rhinitis,
and atopic dermatitis endotypes under the auspices of the PRACTALL collaboration …

Background Many patients with asthma have uncontrolled disease despite treatment with
inhaled glucocorticoids. One potential cause of the variability in response to treatment is …

The chronic lung diseases, asthma and chronic obstructive pulmonary disease (COPD), are
common affecting over 500 million people worldwide and causing substantial morbidity and …

Approximately 5–10% of asthmatic patients worldwide suffer from severe asthma.
Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in …

BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes …