The pediatrician plays a major role in helping optimize bone health in children and
adolescents. This clinical report reviews normal bone acquisition in infants, children, and …

A new paradigm has emerged for osteogenesis imperfecta as a collagen-related disorder.
The more prevalent autosomal dominant forms of osteogenesis imperfecta are caused by …

Background Osteogenesis imperfecta is caused by a genetic defect resulting in an abnormal
type I collagen bone matrix which typically results in multiple fractures with little or no …

The processes of bone growth, modeling, and remodeling determine the structure, mass,
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …

Osteogenesis imperfecta is a genetic disorder characterized by low bone mass, decreased
bone strength, increased bone fragility, and shortened stature. Autosomal dominant …

Osteogenesis imperfecta (OI) is the most prevalent heritable bone fragility disorder in
children. It has been known for three decades that the majority of individuals with OI have …

Osteogenesis imperfecta (OI) is the most common inherited form of bone fragility and
includes a heterogenous group of genetic disorders which most commonly result from …

Osteogenesis imperfecta, or brittle bone disease, is a congenital disease that primarily
causes low bone mass and bone fractures but it can negatively affect other organs. It is …

This article reviews the manifestations and risk factors associated with osteoporosis in
childhood, the definition of osteoporosis and recommendations for monitoring and …

Objectives: Osteogenesis imperfecta (OI) is a rare hereditary disease leading to bone
fragility. Denosumab as a RANK ligand antibody inhibiting osteoclast maturation has been …