Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Anti-diabetic drugs recent approaches and advancements
J Dowarah, VP Singh - Bioorganic & medicinal chemistry, 2020 - Elsevier
Diabetes is one of the major diseases worldwide and is the third leading cause of death in
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
Probing 2-acetylbenzofuran hydrazones and their metal complexes as α-glucosidase inhibitors
Inhibition of α-glucosidase is one of the important approaches in designing antidiabetic
drugs for its role in decrease of the carbohydrates digestion to avoid post-prandial increase …
drugs for its role in decrease of the carbohydrates digestion to avoid post-prandial increase …
Pyrazole scaffold‐based derivatives: A glimpse of α‐glucosidase inhibitory activity, SAR, and route of synthesis
The α‐glucosidase is a validated target to develop drugs for treating type 2 diabetes
mellitus. The existing α‐glucosidase inhibitors have certain shortcomings related to side …
mellitus. The existing α‐glucosidase inhibitors have certain shortcomings related to side …
Imidazole-pyrazole hybrids: Synthesis, characterization and in-vitro bioevaluation against α-glucosidase enzyme with molecular docking studies
Herein, substituted imidazole-pyrazole hybrids (2a-2n) were prepared via a multi component
reaction employing pyrazole-4-carbaldehydes (1a-1d), ammonium acetate, benzil and …
reaction employing pyrazole-4-carbaldehydes (1a-1d), ammonium acetate, benzil and …
Synthesis, structural characterisation and theoretical studies of a novel pyridazine derivative: Investigations of anti-inflammatory activity and inhibition of α-glucosidase
X-ray crystallography on pyridazine 1 (ethyl 2-(3-methyl-4-(4-methylbenzyl)-6-oxopyridazin-
1 (6H)-yl) acetate) shows the planar pyridazinyl ring to exhibit significant delocalisation of π …
1 (6H)-yl) acetate) shows the planar pyridazinyl ring to exhibit significant delocalisation of π …
Evaluation of α-glucosidase inhibiting potentials with docking calculations of synthesized arylidene-pyrazolones
F Chaudhry, S Naureen, S Choudhry, R Huma… - Bioorganic …, 2018 - Elsevier
Herein, condensation of aryl (hetaryl) pyrazole-4-carbaldehydes 1 (ac) with substituted
pyrazolones 2 (ad) lead to the corresponding arylidene-pyrazolones 3 (al) which were …
pyrazolones 2 (ad) lead to the corresponding arylidene-pyrazolones 3 (al) which were …
Synthesis, molecular structure, spectral characterization, and biological activities of ethyl 2-(4-(4-chlorobenzyl)-3-methyl-6-oxopyridazin-1 (6H)-yl) acetate
The structure of the ethyl 2-(4-(4-chlorobenzyl)-3-methyl-6-oxopyridazin-1 (6H)-yl) acetate
(COAP) was revealed using single crystal X-ray diffraction method, was solved and refined …
(COAP) was revealed using single crystal X-ray diffraction method, was solved and refined …
A Review on the Development of Novel Heterocycles as α-Glucosidase Inhibitors for the Treatment of Type-2 Diabetes Mellitus
One of the most effective therapeutic decencies in the treatment of Type 2 Diabetes Mellitus
is the inhibition of α-glucosidase enzyme, which is present at the brush border of the …
is the inhibition of α-glucosidase enzyme, which is present at the brush border of the …