The majority of human mRNAs generate alternative 3′ untranslated regions (UTRs)
through various processes, including RNA modifications such as RNA editing, m 6 A …

It is well established that somatic mutations and escape of immune disruption are two
essential factors in cancer initiation and progression. With an increasing number of second …

Triple-negative breast cancer (TNBC) is the deadliest form of breast cancer. Unlike other
types of breast cancer that can be effectively treated by targeted therapies, no such targeted …

It is well known that the stability of RNA, the interaction between RNA and protein, and the
correct translation of protein are significant forces that drive the transition from normal cell to …

APOBEC3 enzymes contribute significantly to DNA mutagenesis in cancer. These enzymes
are also capable of converting C bases at specific positions of RNAs to U. However, the …

Aims Breast cancer is one of the leading causes of woman deaths worldwide, being a major
public health problem. It has been reported that the expression of the RNA-editing enzyme …

Abstract Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in
eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA …

Background RNA editing generates modifications to the RNA sequences, thereby increasing
protein diversity and shaping various layers of gene regulation. Recent studies have …

The regulation of immune responses by tumors is central to their survival. By diminishing the
production of interferon (IFN) and other inflammatory mediators, tumors enhance immune …

Simple Summary Recent evidence from whole-exome and whole-genome sequencing
approaches revealed a complex genomic landscape for many cancers. In addition to …