Abstract Transient Receptor Potential channels from the vanilloid subfamily (TRPV) are a
group of cation channels modulated by a variety of endogenous stimuli as well as a range of …

The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1),
has been identified as a polymodal transducer molecule on a sub-set of primary sensory …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

The transient receptor potential (TRP) ion channel family is involved in a diversity of
physiological processes including sensory and homeostatic functions, as well as muscle …

TRP-channels are the most prominent family of ligand-gated ion channels for pain
perception. In sensory neurons, TRPV1–V4, TRPA1 and TRPM8 are expressed and are …

Transient receptor potential vanilloid 1 (TRPV1) has been shown to alter its ionic selectivity
profile in a time-and agonist-dependent manner. One hallmark of this dynamic process is an …

Cholesterol is an essential constituent of cell membranes. The discovery of cholesterol‐
recognition amino acid consensus (CRAC) motif in proteins indicated a putative direct, non …

Ion channels allow for rapid ion diffusion through the plasma membrane. In some conditions,
ion channels induce changes in the critical plasma membrane permeability that permit 900 …

TRPV1 is a thermo-sensitive ion channel involved in neurosensory and other physiological
functions. The trans-membrane helices of TRPV1 undergo quick and complex …

BACKGROUND: Inhibitors of cyclooxygenase, which block the formation of prostaglandin
(PG) E2, are the standard treatment of inflammatory pain. These drugs, however, have …