Mitigating off‐target effects of small RNAs: conventional approaches, network theory and artificial intelligence

Z Bereczki, B Benczik, OM Balogh… - British Journal of …, 2025 - Wiley Online Library
Three types of highly promising small RNA therapeutics, namely, small interfering RNAs
(siRNAs), microRNAs (miRNAs) and the RNA subtype of antisense oligonucleotides (ASOs) …

DIANA-miRPath v4. 0: expanding target-based miRNA functional analysis in cell-type and tissue contexts

S Tastsoglou, G Skoufos, M Miliotis… - Nucleic Acids …, 2023 - academic.oup.com
DIANA-miRPath is an online miRNA analysis platform harnessing predicted or
experimentally supported miRNA interactions towards the exploration of combined miRNA …

TarBase-v9. 0 extends experimentally supported miRNA–gene interactions to cell-types and virally encoded miRNAs

G Skoufos, P Kakoulidis, S Tastsoglou… - Nucleic Acids …, 2024 - academic.oup.com
TarBase is a reference database dedicated to produce, curate and deliver high quality
experimentally-supported microRNA (miRNA) targets on protein-coding transcripts. In its …

[HTML][HTML] The Role of the MiR-181 Family in Hepatocellular Carcinoma

J Chen, K Liu, MA Vadas, JR Gamble, GW McCaughan - Cells, 2024 - mdpi.com
Hepatocellular carcinoma (HCC) is the fourth-leading cause of cancer-related death
worldwide. Due to the high mortality rate in HCC patients, discovering and developing novel …

Unveiling the unique role of TSPAN7 across tumors: a pan-cancer study incorporating retrospective clinical research and bioinformatic analysis

B Lu, Y Liu, Y Yao, D Zhu, X Zhang, K Dong, X Xu, D Lv… - Biology Direct, 2024 - Springer
Background TSPAN7 is an important factor in tumor progression. However, the precise
function of TSPAN7 and its role in pan-cancer are not clear. Methods Based on Xinhua …

Heart failure with preserved ejection fraction in pigs causes shifts in posttranscriptional checkpoints

SL Samani, SC Barlow, LA Freeburg… - American Journal …, 2024 - journals.physiology.org
Left ventricular pressure overload (LVPO) can lead to heart failure with a preserved ejection
fraction (HFpEF) and LV chamber stiffness (LV K c) is a hallmark. This project tested the …

[HTML][HTML] An In-Depth Approach to the Associations between MicroRNAs and Viral Load in Patients with Chronic Hepatitis B—A Systematic Review and Meta-Analysis

M Manea, I Mărunțelu, I Constantinescu - International Journal of …, 2024 - mdpi.com
Scientists study the molecular activities of the hepatitis B virus (HBV). However, in vivo
experiments are scarce. Some microRNAs are HBV-related, but their exact mechanisms are …

[HTML][HTML] Clinical significance of disulfidptosis-related genes and functional analysis in gastric Cancer

J Yan, Z Fang, M Shi, C Tu, S Zhang, C Jiang… - Journal of …, 2024 - ncbi.nlm.nih.gov
Background: Worldwide, gastric cancer (GC) remains intractable due to its poor prognosis
and high morbidity and mortality. Disulfidptosis is a novel kind of cell death mediated by …

Luteolin inhibits lung cancer cell migration by negatively regulating TWIST1 and MMP2 through upregulation of miR-106a-5p

Q Wang, M Chen, X Tang - Integrative Cancer Therapies, 2024 - journals.sagepub.com
Background: Luteolin, a common dietary flavonoid found in plants, has been shown to have
anti-cancer properties. However, its exact mechanisms of action in non-small cell lung …

Hepatitis B Virus and microRNAs: A Bioinformatics Approach

V Zulian, G Fiscon, P Paci, AR Garbuglia - International Journal of …, 2023 - mdpi.com
In recent decades, microRNAs (miRNAs) have emerged as key regulators of gene
expression, and the identification of viral miRNAs (v-miRNAs) within some viruses, including …