Crohn's disease (CD) and ulcerative colitis (UC) are both highly inflammatory diseases of
the gastrointestinal tract, collectively known as inflammatory bowel disease (IBD). Although …

The gut microbiota plays a major role in the developmental biology and homeostasis of cells
belonging to the adaptive and innate arms of the immune system. Alterations in its …

Inflammatory bowel diseases (IBDs) result in diarrhea and abdominal pain with further
potential complications such as tissue fibrosis and stenosis. Animal models help in …

The specific pathogenesis underlining inflammatory bowel disease (IBD) is very
complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major …

The complete repair of the mucosa constitutes a key goal in inflammatory bowel disease
(IBD) treatment. The Wnt signaling pathway mediates mucosal repair and M2 macrophages …

Eosinophils are leukocytes which reside in the gastrointestinal tract under homeostatic
conditions, except for the esophagus which is normally devoid of eosinophils. Research on …

Pathogenesis of the inflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) and
Crohn's disease (CD), involve proinflammatory changes within the microbiota, chronic …

Work in large part on Leishmania major in the 1980s identified two distinct apparently
counter-regulatory CD4+ T cell populations, T helper (h) 1 and Th2, that controlled …

Inflammatory bowel diseases, ulcerative colitis and Crohn׳ s disease are characterized by
chronic relapsing inflammation of the gastrointestinal tract of unknown etiology that seems to …

During the last decade, biological therapies have an increasing share in the modern
therapeutics of various diseases including inflammatory bowel diseases (IBD). Animal …