Cytochrome P450 2J2: potential role in drug metabolism and cardiotoxicity
M Solanki, A Pointon, B Jones, K Herbert - Drug Metabolism and Disposition, 2018 - ASPET
Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)–
derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome …
derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome …
Role of epoxyeicosatrienoic acids in cardiovascular diseases and cardiotoxicity of drugs
Y Zhang, L Gao, B Yao, S Huang, Y Zhang, J Liu, Z Liu… - Life Sciences, 2022 - Elsevier
Epoxyeicosatrienoic acids (EETs) are important endogenous substances that affect heart
function in human body. Animal models of cytochrome P450 (CYP) and soluble epoxide …
function in human body. Animal models of cytochrome P450 (CYP) and soluble epoxide …
[HTML][HTML] Quercetin inhibits the metabolism of arachidonic acid by inhibiting the activity of CYP3A4, thereby inhibiting the progression of breast cancer
H Tang, Y Kuang, W Wu, B Peng, Q Fu - Molecular Medicine, 2023 - Springer
Background Recent years have witnessed impressive growth in applying natural medicine
in tumor treatment. Saffron is reported to elicit an inhibitory property against BC. Herein, we …
in tumor treatment. Saffron is reported to elicit an inhibitory property against BC. Herein, we …
[HTML][HTML] Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts
AV Karkhanis, G Venkatesan, R Kambayashi… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract Cytochrome P4502J2 (CYP2J2) metabolizes arachidonic acid (AA) to
cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug …
cardioprotective epoxyeicosatrienoic acids (EETs). Dronedarone, an antiarrhythmic drug …
[HTML][HTML] Investigating the relevance of CYP2J2 inhibition for drugs known to cause intermediate to high risk torsades de pointes
JWH Leow, Y Gu, ECY Chan - European Journal of Pharmaceutical …, 2023 - Elsevier
Abstract Cardiac cytochrome P450 2J2 (CYP2J2) metabolizes endogenous polyunsaturated
fatty acid, arachidonic acid (AA), to bioactive regioisomeric epoxyeicosatrienoic acid (EET) …
fatty acid, arachidonic acid (AA), to bioactive regioisomeric epoxyeicosatrienoic acid (EET) …
Inhibition of cytochrome P450 2J2-mediated metabolism of rivaroxaban and arachidonic acid by ibrutinib and osimertinib
Covalent tyrosine kinase inhibitors (TKIs) ibrutinib and osimertinib are associated with
cardiac arrhythmia. The interactions between these TKIs with CYP2J2 that is highly …
cardiac arrhythmia. The interactions between these TKIs with CYP2J2 that is highly …
Cardiomyocyte-specific CYP2J2 and its therapeutic implications
R Valencia, W Bassiouni, AM Darwesh… - Expert Opinion on …, 2022 - Taylor & Francis
ABSTRACT Introduction Cytochrome P450s (CYPs) are a superfamily of monooxygenases
with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it …
with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it …
CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control
JWH Leow, ECY Chan - Pharmacology & Therapeutics, 2024 - Elsevier
Abstract Cytochrome P450 2 J2 (CYP2J2) is primarily expressed extrahepatically and is the
predominant epoxygenase in human cardiac tissues. This highlights its key role in the …
predominant epoxygenase in human cardiac tissues. This highlights its key role in the …
Atypical kinetics of cytochrome P450 2J2: epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors
Extrahepatic CYP2J2 metabolism of arachidonic acid (AA) to bioactive regioisomeric
epoxyeicosatrienoic acids (EETs) is implicated in both physiological and pathological …
epoxyeicosatrienoic acids (EETs) is implicated in both physiological and pathological …
Investigation of doxorubicin combined with ciprofloxacin-induced cardiotoxicity: from molecular mechanism to fundamental heart function
This study was designed to investigate the impacts of Doxo alone and in combination with
Cipro on the hepatic and cardiac CYP1A2, CYP2J3, and CYP3A1 mRNA levels. We also …
Cipro on the hepatic and cardiac CYP1A2, CYP2J3, and CYP3A1 mRNA levels. We also …