The investigational drug dichloroacetate (DCA) is a metabolic regulator that has been
successfully used to treat acquired and congenital metabolic diseases and, recently, solid …

Sodium dichloroacetate (DCA) is an investigational medicinal product which has a potential
anticancer preparation as a metabolic regulator in cancer cells' mitochondria. Inhibition of …

An important approach in tumor therapy is combining substances with different action
mechanisms aiming to enhance the antineoplastic effect, decrease the therapeutic dosage …

The Warburg effect describes the ability of cancer cells to produce energy via aerobic
glycolysis instead of oxidative phosphorylation of pyruvate. This deviation in mitochondrial …

Dichloroacetate (DCA) is a promising safe anticancer drug that cured a patient with
chemoresistant non-Hodgkin's lymphoma and treated lactic acidosis effectively. The well …

Rarely has a chemical elicited as much controversy as dichloroacetate (DCA). DCA was
initially considered a dangerous toxic industrial waste product, then a potential treatment for …

Targeting mitochondrial energy metabolism is a novel approach in cancer research and can
be traced back to the description of the Warburg effect. Dichloroacetate, a controversially …

Enriched in glycolytic enzymes, paucicellular and hypovascular intrasynovial flexor tendons
fail to mount an effective healing response after injury and repair. In contrast, well …

Mastectomy is the standard treatment for mammary gland tumors in dogs. In addition to
traditional therapy, sodium dichloroacetate (DCA) can act as target therapy, as it may …

Dichloroacetic acid (DCA), a halogenated organic acid, is a pyruvate dehydrogenase kinase
inhibitor that has been used to treat congenital or acquired lactic acidosis and is currently in …