Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine

MB Murphy, K Moncivais, AI Caplan - Experimental & molecular …, 2013 - nature.com
Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into
tissues including bone, cartilage and adipose in vitro, but it is their trophic, paracrine and …

Therapeutic applications of mesenchymal stromal cells: paracrine effects and potential improvements

J Doorn, G Moll, K Le Blanc… - … Engineering Part B …, 2012 - liebertpub.com
Among the various types of cell-to-cell signaling, paracrine signaling comprises those
signals that are transmitted over short distances between different cell types. In the human …

Multipotent stem cell and current application

A Sobhani, N Khanlarkhani, M Baazm… - Acta Medica …, 2017 - acta.tums.ac.ir
Stem cells are self-renewing and undifferentiated cell types that can be differentiate into
functional cells. Stem cells can be classified into two main types based on their source of …

The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment

DG Leuning, NRM Beijer, NA Du Fossé, S Vermeulen… - Scientific reports, 2018 - nature.com
Mesenchymal stromal cells (MSC) secrete factors that contribute to organ homeostasis and
repair in a tissue specific manner. For instance, kidney perivascular mesenchymal stromal …

Strategies to optimize adult stem cell therapy for tissue regeneration

S Liu, J Zhou, X Zhang, Y Liu, J Chen, B Hu… - International journal of …, 2016 - mdpi.com
Stem cell therapy aims to replace damaged or aged cells with healthy functioning cells in
congenital defects, tissue injuries, autoimmune disorders, and neurogenic degenerative …

Therapeutic application of multipotent stem cells

H Mirzaei, A Sahebkar, LS Sichani… - Journal of cellular …, 2018 - Wiley Online Library
Cell therapy is an emerging fields in the treatment of various diseases such as
cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool …

Biomimetic tissue‐engineered bone substitutes for maxillofacial and craniofacial repair: The potential of cell sheet technologies

F Kawecki, WP Clafshenkel, M Fortin… - Advanced …, 2018 - Wiley Online Library
Maxillofacial defects are complex lesions stemming from various etiologies: accidental,
congenital, pathological, or surgical. A bone graft may be required when the normal …

Adipose-derived stem cell sheets accelerate bone healing in rat femoral defects

Y Yoshida, H Matsubara, X Fang, K Hayashi, I Nomura… - PloS one, 2019 - journals.plos.org
In the present study, we investigated whether both adipose-derived stem cell (ADSC) and
osteogenic-induced ADSC sheets could promote bone healing in a rat distal femoral …

Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules

CE Segar, ME Ogle… - Current pharmaceutical …, 2013 - ingentaconnect.com
Regeneration of bone requires the coordinated processes of angiogenesis and
osteogenesis. These repair mechanisms are closely linked through both direct cell-cell …

Mapping calcium phosphate activated gene networks as a strategy for targeted osteoinduction of human progenitors

J Eyckmans, SJ Roberts, J Bolander, J Schrooten… - Biomaterials, 2013 - Elsevier
Although calcium phosphate-containing biomaterials are promising scaffolds for bone
regenerative strategies, the osteoinductive capacity of such materials is poorly understood …