Natural steroidal estrogen hormones, eg, estrone (E1), 17β-estradiol (E2), estriol (E3), and
17α-estradiol (17α), are released by humans and livestock in the environment and are the …

17β-Hydroxysteroid dehydrogenases (17β-HSDs) are oxidoreductases, which play a key
role in estrogen and androgen steroid metabolism by catalyzing final steps of the steroid …

Short‐chain dehydrogenases/reductases (SDRs) are enzymes of great functional diversity.
Even at sequence identities of typically only 15–30%, specific sequence motifs are …

Pichia stipitisNAD+-dependent xylitol dehydrogenase (XDH), a medium-chain
dehydrogenase/reductase, is one of the key enzymes in ethanol fermentation from xylose …

Abstract Hydroxysteroid 17-beta-dehydrogenase 13 (HSD17B13) is a hepatic lipid droplet-
associated enzyme that is upregulated in patients with non-alcoholic fatty liver disease …

Homology modeling was used to identify two particular residues, Glu175 and Ala176, in
Pseudomonas stutzeri phosphite dehydrogenase (PTDH) as the principal determinants of …

Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit
receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary …

Oxidoreductases are ubiquitous enzymes that catalyze an extensive range of chemical
reactions with great specificity, efficiency, and selectivity. Most oxidoreductases are …

Hydroxysteroid dehydrogenases (HSDs) interconvert potent and relatively inactive forms of
individual steroid hormones using nicotinamide cofactors NADPH/NADP+ and NADH/NAD+ …

At the late 1940s, 17β-HSD1 was discovered as the first member of the 17β-HSD family with
its gene cloned. The three-dimensional structure of human 17β-HSD1 is the first example of …