Vascular aging is a major risk factor for age-related cardiovascular diseases, which have
high rates of morbidity and mortality. It is characterized by changes in the blood vessels …

DNA Damage Tolerance (DDT) functions to bypass replication-blocking lesions and is
divided into two distinct pathways: error-prone Translesion Synthesis (TLS) and error-free …

DNA damage tolerance (DDT), activated by replication stress during genome replication, is
mediated by translesion synthesis and homologous recombination (HR). Here we uncover …

DNA lesions escaping from repair often block the DNA replicative polymerases required for
DNA replication and are handled during the S/G2 phases by the DNA damage tolerance …

The DNA damage response (DDR) preserves the genetic integrity of the cell by sensing and
repairing damages after a genotoxic stress. Translesion Synthesis (TLS), an error-prone …

The bypass of DNA lesions that block replicative polymerases during DNA replication relies
on DNA damage tolerance pathways. The error-prone translesion synthesis (TLS) pathway …

The sustainment of replication and transcription of damaged DNA is essential for cell
survival under genotoxic stress; however, the damage tolerance of these key cellular …

Stalled replication forks can be processed by several distinct mechanisms collectively called
post-replication repair which includes homologous recombination, fork regression, and …

DNA lesions are a threat for genome stability. In order to cope with these lesions, cells have
evolved lesion tolerance mechanisms: Translesion Synthesis (TLS) that allows the cell to …

DNA lesions are a threat to genome stability. In order to cope with these lesions, cells have
evolved lesion tolerance mechanisms: Translesion Synthesis (TLS) that allows the cell to …