The neuroprotective potentiality of flavonoids on Alzheimer's disease

A Calderaro, GT Patanè, E Tellone, D Barreca… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD), due to its spread, has become a global health priority, and is
characterized by senile dementia and progressive disability. The main cause of AD and …

Epigallocatechin-3-Gallate (EGCG): New therapeutic perspectives for neuroprotection, aging, and neuroinflammation for the modern age

A Payne, S Nahashon, E Taka, GM Adinew… - Biomolecules, 2022 - mdpi.com
Alzheimer's and Parkinson's diseases are the two most common forms of neurodegenerative
diseases. The exact etiology of these disorders is not well known; however, environmental …

Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro

PM Seidler, KA Murray, DR Boyer, P Ge… - Nature …, 2022 - nature.com
Alzheimer's disease (AD) is the consequence of neuronal death and brain atrophy
associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils …

A closer look at amyloid ligands, and what they tell us about protein aggregates

TS Chisholm, CA Hunter - Chemical Society Reviews, 2024 - pubs.rsc.org
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …

Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases

PB Gonçalves, ACR Sodero, Y Cordeiro - Biomolecules, 2021 - mdpi.com
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …

Potential role of natural polyphenols against protein aggregation toxicity: in vitro, in vivo, and clinical studies

G Henríquez, A Gomez, E Guerrero… - ACS Chemical …, 2020 - ACS Publications
One of the main features of neurodegenerative disorders such as Alzheimer's disease and
Parkinson's disease is the amyloidogenic behavior of disease-specific proteins including …

Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease

H Verma, P Gangwar, A Yadav, B Yadav, R Rao… - Mitochondrion, 2023 - Elsevier
Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …

Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils

KA Murray, CJ Hu, H Pan, J Lu… - Proceedings of the …, 2023 - National Acad Sciences
The amyloid aggregation of alpha-synuclein within the brain is associated with the
pathogenesis of Parkinson's disease (PD) and other related synucleinopathies, including …

Non-enzymatic antioxidants against Alzheimer's disease: prevention, diagnosis and therapy

A Varesi, LIM Campagnoli, A Carrara, I Pola, E Floris… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory loss and cognitive decline. Although substantial research has been conducted to …

Potential therapeutic role of phytochemicals to mitigate mitochondrial dysfunctions in Alzheimer's disease

MA Rahman, MDH Rahman, P Biswas, MS Hossain… - Antioxidants, 2020 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a
decline in cognitive function and neuronal damage. Although the precise pathobiology of AD …