The neuroprotective potentiality of flavonoids on Alzheimer's disease
Alzheimer's disease (AD), due to its spread, has become a global health priority, and is
characterized by senile dementia and progressive disability. The main cause of AD and …
characterized by senile dementia and progressive disability. The main cause of AD and …
Epigallocatechin-3-Gallate (EGCG): New therapeutic perspectives for neuroprotection, aging, and neuroinflammation for the modern age
A Payne, S Nahashon, E Taka, GM Adinew… - Biomolecules, 2022 - mdpi.com
Alzheimer's and Parkinson's diseases are the two most common forms of neurodegenerative
diseases. The exact etiology of these disorders is not well known; however, environmental …
diseases. The exact etiology of these disorders is not well known; however, environmental …
Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro
Alzheimer's disease (AD) is the consequence of neuronal death and brain atrophy
associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils …
associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils …
A closer look at amyloid ligands, and what they tell us about protein aggregates
TS Chisholm, CA Hunter - Chemical Society Reviews, 2024 - pubs.rsc.org
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …
Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
Potential role of natural polyphenols against protein aggregation toxicity: in vitro, in vivo, and clinical studies
G Henríquez, A Gomez, E Guerrero… - ACS Chemical …, 2020 - ACS Publications
One of the main features of neurodegenerative disorders such as Alzheimer's disease and
Parkinson's disease is the amyloidogenic behavior of disease-specific proteins including …
Parkinson's disease is the amyloidogenic behavior of disease-specific proteins including …
Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease
H Verma, P Gangwar, A Yadav, B Yadav, R Rao… - Mitochondrion, 2023 - Elsevier
Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils
The amyloid aggregation of alpha-synuclein within the brain is associated with the
pathogenesis of Parkinson's disease (PD) and other related synucleinopathies, including …
pathogenesis of Parkinson's disease (PD) and other related synucleinopathies, including …
Non-enzymatic antioxidants against Alzheimer's disease: prevention, diagnosis and therapy
A Varesi, LIM Campagnoli, A Carrara, I Pola, E Floris… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory loss and cognitive decline. Although substantial research has been conducted to …
memory loss and cognitive decline. Although substantial research has been conducted to …
Potential therapeutic role of phytochemicals to mitigate mitochondrial dysfunctions in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a
decline in cognitive function and neuronal damage. Although the precise pathobiology of AD …
decline in cognitive function and neuronal damage. Although the precise pathobiology of AD …