The prevailing notion that reduced cofactors NADH and FADH 2 transfer electrons from the
tricarboxylic acid cycle to the mitochondrial electron transfer system creates ambiguities …

Friedreich's ataxia (FRDA) is a rare childhood neurologic disorder, affecting 1 in 50,000
Caucasians. The disease is caused by the abnormal expansion of the GAA repeat sequence …

Let us first start where we all agree: KATP channels are the main conductance of the resting
pancreatic b-cell, and their closure by changes in the ATP/ADP ratio is the triggering …

Hearing loss is a prevalent condition affecting millions of people worldwide. Hearing loss
has been linked to oxidative stress as a major factor in its onset and progression. The goal of …

In vivo control over metabolism is at the cutting edge of biomedical research. The particulars
of mitochondrial function are especially important to understand in vivo to progress …

Changes in mitochondrial function play a critical role in the basic biology of aging and age-
related disease. Mitochondria are typically thought of in the context of ATP production and …

Peripheral mononuclear cells (PBMCs) exhibit robust changes in mitochondrial respiratory
capacity in response to health and disease. While these changes do not always reflect what …