[HTML][HTML] Disrupted neuronal trafficking in amyotrophic lateral sclerosis
K Burk, RJ Pasterkamp - Acta neuropathologica, 2019 - Springer
Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disease
caused by degeneration of motor neurons in the brain and spinal cord leading to muscle …
caused by degeneration of motor neurons in the brain and spinal cord leading to muscle …
Lysosomal dysfunction at the centre of Parkinson's disease and frontotemporal dementia/amyotrophic lateral sclerosis
Parkinson's disease (PD) and frontotemporal dementia/amyotrophic lateral sclerosis
(FTD/ALS) are insidious and incurable neurodegenerative diseases that represent a …
(FTD/ALS) are insidious and incurable neurodegenerative diseases that represent a …
[HTML][HTML] Impairment of lysosome function and autophagy in rare neurodegenerative diseases
F Darios, G Stevanin - Journal of molecular biology, 2020 - Elsevier
Rare genetic diseases affect a limited number of patients, but their etiology is often known,
facilitating the development of reliable animal models and giving the opportunity to …
facilitating the development of reliable animal models and giving the opportunity to …
[HTML][HTML] Preserving lysosomal function in the aging brain: insights from neurodegeneration
Lysosomes are acidic, membrane-bound organelles that serve as the primary catabolic
compartment of the cell. They are crucial to a variety of cellular processes from nutrient …
compartment of the cell. They are crucial to a variety of cellular processes from nutrient …
Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies
Genetic variants that define two distinct haplotypes at the TMEM106B locus have been
implicated in multiple neurodegenerative diseases and in healthy brain ageing. In …
implicated in multiple neurodegenerative diseases and in healthy brain ageing. In …
[HTML][HTML] Genetic architecture of common non-Alzheimer's disease dementias
Frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and vascular dementia
(VaD) are the most common forms of dementia after Alzheimer's disease (AD). The …
(VaD) are the most common forms of dementia after Alzheimer's disease (AD). The …
A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination
TMEM106B encodes a lysosomal membrane protein and was initially identified as a risk
factor for frontotemporal lobar degeneration. Recently, a dominant D252N mutation in …
factor for frontotemporal lobar degeneration. Recently, a dominant D252N mutation in …
Loss of TMEM 106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice
Single nucleotide polymorphisms (SNP s) in TMEM 106B encoding the lysosomal type II
transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) …
transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) …
[HTML][HTML] The converging roles of sequestosome-1/p62 in the molecular pathways of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
JM Davidson, RS Chung, A Lee - Neurobiology of Disease, 2022 - Elsevier
Investigations into the pathogenetic mechanisms underlying amyotrophic lateral sclerosis
(ALS) and frontotemporal dementia (FTD) have provided significant insight into the disease …
(ALS) and frontotemporal dementia (FTD) have provided significant insight into the disease …
[HTML][HTML] The FTLD risk factor TMEM106B regulates the transport of lysosomes at the axon initial segment of motoneurons
Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect
frontotemporal lobar degeneration (FTLD) in GRN-(coding for progranulin) and C9orf72 …
frontotemporal lobar degeneration (FTLD) in GRN-(coding for progranulin) and C9orf72 …