PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
Readout of epigenetic modifications
DJ Patel, Z Wang - Annual review of biochemistry, 2013 - annualreviews.org
This review focuses on a structure-based analysis of histone posttranslational modification
(PTM) readout, where the PTMs serve as docking sites for reader modules as part of larger …
(PTM) readout, where the PTMs serve as docking sites for reader modules as part of larger …
The piRNA pathway guards the germline genome against transposable elements
KF Tóth, D Pezic, E Stuwe, A Webster - Non-coding RNA and the …, 2016 - Springer
Transposable elements (TEs) have the capacity to replicate and insert into new genomic
locations. This contributs significantly to evolution of genomes, but can also result in DNA …
locations. This contributs significantly to evolution of genomes, but can also result in DNA …
RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts
Summary Germline-specific Piwi-interacting RNAs (piRNAs) protect animal genomes
against transposons and are essential for fertility. piRNAs targeting active transposons are …
against transposons and are essential for fertility. piRNAs targeting active transposons are …
Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline
Piwi proteins and Piwi‐interacting RNAs (piRNAs) repress transposition, regulate
translation, and guide epigenetic programming in the germline. Here, we show that an …
translation, and guide epigenetic programming in the germline. Here, we show that an …
Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline
JH Crichton, DS Dunican, M MacLennan… - Cellular and molecular …, 2014 - Springer
The viability of any species requires that the genome is kept stable as it is transmitted from
generation to generation by the germ cells. One of the challenges to transgenerational …
generation to generation by the germ cells. One of the challenges to transgenerational …
TDRD1 phase separation drives intermitochondrial cement assembly to promote piRNA biogenesis and fertility
J Gao, J Jing, G Shang, C Chen, M Duan, W Yu… - Developmental Cell, 2024 - cell.com
The intermitochondrial cement (IMC) is a prominent germ granule that locates among
clustered mitochondria in mammalian germ cells. Serving as a key platform for Piwi …
clustered mitochondria in mammalian germ cells. Serving as a key platform for Piwi …
A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans
piRNAs play a critical role in the regulation of transposons and other germline genes. In
Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator …
Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator …
A structural perspective on readout of epigenetic histone and DNA methylation marks
DJ Patel - Cold Spring Harbor perspectives in biology, 2016 - cshperspectives.cshlp.org
This article outlines the protein modules that target methylated lysine histone marks and
5mC DNA marks, and the molecular principles underlying recognition. The article focuses …
5mC DNA marks, and the molecular principles underlying recognition. The article focuses …
Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice
Piwi-interacting RNAs (piRNAs) are gonad-specific small RNAs that provide defense against
transposable genetic elements called transposons. Our knowledge of piRNA biogenesis is …
transposable genetic elements called transposons. Our knowledge of piRNA biogenesis is …