The Evolutionary Interplay of Somatic and Germline Mutation Rates
AC Beichman, L Zhu, K Harris - Annual Review of Biomedical …, 2024 - annualreviews.org
Novel sequencing technologies are making it increasingly possible to measure the mutation
rates of somatic cell lineages. Accurate germline mutation rate measurement technologies …
rates of somatic cell lineages. Accurate germline mutation rate measurement technologies …
The mutagenic consequences of defective DNA repair
E Németh, D Szüts - DNA repair, 2024 - Elsevier
Multiple separate repair mechanisms safeguard the genome against various types of DNA
damage, and their failure can increase the rate of spontaneous mutagenesis. The …
damage, and their failure can increase the rate of spontaneous mutagenesis. The …
NeMu: a comprehensive pipeline for accurate reconstruction of neutral mutation spectra from evolutionary data
The recognized importance of mutational spectra in molecular evolution is yet to be fully
exploited beyond human cancer studies and model organisms. The wealth of intraspecific …
exploited beyond human cancer studies and model organisms. The wealth of intraspecific …
k-mer-based approaches to bridging pangenomics and population genetics
MD Roberts, O Davis, EB Josephs… - arXiv preprint arXiv …, 2024 - arxiv.org
Many commonly studied species now have more than one chromosome-scale genome
assembly, revealing a large amount of genetic diversity previously missed by approaches …
assembly, revealing a large amount of genetic diversity previously missed by approaches …
The evolution and convergence of mutation spectra across mammals
Despite the key role genetic mutations play in shaping phenotypic differences between
species, little is currently known about the evolution of germline mutation spectra across …
species, little is currently known about the evolution of germline mutation spectra across …
Robust inference of historical human generation times
Abstract raise concerns about our recent estimates of historical human generation times,
concluding that our results were “predominantly driven by nonbiological artifacts.” While we …
concluding that our results were “predominantly driven by nonbiological artifacts.” While we …
Characterizing Mutagenesis Across Developmental Time with single-cell indexing (sci) ATAC-seq
YC Pan - 2024 - search.proquest.com
Mutations in DNA are caused by replication errors or exposure to mutagen that damage the
DNA repair mechanisms. Germline variants are mutations that occur in germ cells and can …
DNA repair mechanisms. Germline variants are mutations that occur in germ cells and can …
Modeling Mutation Rate Variation over Time Using Bayesian Sequence Context Mutational Trees
CJ Adams - 2023 - search.proquest.com
Germline mutation is the mechanism by which genetic variation in a population is created. It
follows that mutation rate models are fundamental to population genetic inference …
follows that mutation rate models are fundamental to population genetic inference …