An intricate interplay between genetic and environmental factors contributes to the
development of type 2 diabetes (T2D) and its complications. Therefore, it is not surprising …

Abstract Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by
mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the …

Neurological disorders are a diverse group of conditions that affect the nervous system and
include neurodegenerative diseases (Alzheimer's disease, multiple sclerosis, Parkinson's …

Metformin is a widely used and effective medication in type 2 diabetes (T2DM) as well as in
polycystic ovary syndrome (PCOS). Single nucleotide polymorphisms (SNPs) contribute to …

Increasing levels of oxidative-stress due to deterioration of the Nrf2 (NFE2-related
factor)/ARE (antioxidant response element) pathway is found to be a primary cause of aging …

Metformin has been used for the treatment of type II diabetes mellitus for decades due to its
safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying …

Solute carriers (SLCs) constitute the largest superfamily of membrane transporter proteins.
These transporters, present in various SLC families, play a vital role in energy metabolism …

Background: Solute Carrier Family 22 Member 1 (SLC22A1, also known as OCT1) protein
has a vital role in the metabolism of metformin, a first-line anti-diabetes medication. Genetic …

Abstract Organic cation transporter 1 (OCT1, gene symbol: SLC22A1) is mainly responsible
for the hepatic uptake of various cationic drugs, closely associated with drug-induced liver …

Platelet-rich fibrin (PRF) is a popular autologous blood-derived biomaterial that is used in
regenerative therapy. Owing to its simple preparation without additional factors, the PRF …