Background Aspirin-exacerbated respiratory disease (AERD) is manifested by adult-onset
asthma, nasal polyposis, chronic rhinosinusitis, and aspirin sensitivity. Previously reported …

Evaluation and effective management of asthma, and in particular severe asthma, remains
at the core of pulmonary practice. Over the last 20–30 years, there has been increasing …

Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …

BACKGROUND: Measurement of biomarkers has been incorporated within clinical research
studies of asthma to characterize the population and associate the disease with …

Aspirin-exacerbated respiratory disease (AERD) is characterized by the clinical triad of
chronic rhinosinusitis with nasal polyps, asthma, and an intolerance to medications that …

In 1979 and 1980, the chemical structures of the material previously known as slow-reacting
substance of anaphylaxis were elucidated as 5 (S)-hydroxy-6 (R)-glutathionyl-7, 9-trans-11 …

This best-selling resource has a worldwide reputation as the leader in its field. Focusing on
human immunology and biology, while also reporting on scientific experimentation and …

The most recent Guidelines for the Diagnosis and Management of Asthma from the National
Asthma Education and Prevention Program define the disease as follows:“Asthma is a …

Objective: To review the biochemistry and biological activities of leukotrienes, focusing on
their role in the mediation of inflammatory diseases. Data Sources: MEDLINE (1966-1994) …

Aspirin causes bronchoconstriction in aspirin-intolerant asthma (AIA) patients by triggering
cysteinyl-leukotriene (cys-LT) production, probably by removing PGE2-dependent inhibition …