The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Calcineurin is a eukaryotic Ca2+-and calmodulin-dependent serine/threonine protein
phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A …

Many distinct signaling pathways allow the cell to receive, process, and respond to
information. Often, components of different pathways interact, resulting in signaling …

WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp
(WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular …

THE tau gene encodes a protein (Tau) that is a major neuronal microtubule-associated
protein localized mostly in axons1–4. It has microtubule-binding and tubulin-polymerizing …

Abstract LONG-TERM potentiation (LTP) is a synaptic mechanism thought to be involved in
learning and memory1. Long-term depression (LTD), an activity-dependent decrease in …

Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase
that regulates an enormous variety of cellular functions through the interaction of its catalytic …

Extracellular signals that promote cell growth activate cascades of protein kinases. The
kinases are dephosphorylated and deactivated by a single type-2A protein phosphatase …

Ceramide activates a cytosolic protein phosphatase present in rat T9 glioma cells and rat
brain. Ceramide-activated protein phosphatase (CAPP) was found to share several …

The effectiveness of long-term potentiation (LTP) as a mechanism for information storage
would be severely limited if processes that decrease synaptic strength did not also exist. In …