Recent Advances in 64Cu/67Cu-Based Radiopharmaceuticals

OO Krasnovskaya, D Abramchuck, A Erofeev… - International Journal of …, 2023 - mdpi.com
Copper-64 (T1/2= 12.7 h) is a positron and beta-emitting isotope, with decay characteristics
suitable for both positron emission tomography (PET) imaging and radiotherapy of cancer …

Advances in non-radioactive PSMA-targeted small molecule-drug conjugates in the treatment of prostate cancer

M Chen, L Cai, Y Xiang, L Zhong, J Shi - Bioorganic Chemistry, 2023 - Elsevier
Most patients with advanced prostate cancer (PCa) will develop metastatic castration-
resistant prostate cancer (mCRPC) after androgen deprivation therapy, at this time the tumor …

Hybrids of Sterically Hindered Phenols and Diaryl Ureas: Synthesis, Switch from Antioxidant Activity to ROS Generation and Induction of Apoptosis

E Gibadullina, M Neganova, Y Aleksandrova… - International Journal of …, 2023 - mdpi.com
The utility of sterically hindered phenols (SHPs) in drug design is based on their
chameleonic ability to switch from an antioxidant that can protect healthy tissues to highly …

Synthesis, characterization, and preclinical evaluation of a small-molecule prostate-specific membrane antigen-targeted monomethyl auristatin E conjugate

AE Machulkin, AA Uspenskaya, NU Zyk… - Journal of Medicinal …, 2021 - ACS Publications
Prostate cancer is the second most common type of cancer among men. Its main method of
treatment is chemotherapy, which has a wide range of side effects. One of the solutions to …

PSMA-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation

AE Machulkin, AA Uspenskaya, NY Zyk… - European Journal of …, 2022 - Elsevier
Prostate cancer is one of the most commonly diagnosed men's cancers and remains one of
the leading causes of cancer death. The development of approaches to the treatment of this …

Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with 177Lu

AE Machulkin, SA Petrov, V Bodenko… - ACS pharmacology & …, 2024 - ACS Publications
177Lu-labeled small-molecule prostate-specific membrane antigen (PSMA) targeted tracers
are therapeutic agents for metastatic castration-resistant prostate cancer. Optimizing …

[HTML][HTML] PSMA-targeted NIR probes for image-guided detection of prostate cancer

A Cilibrizzi, JTW Wang, S Memdouh, A Iacovone… - Colloids and Surfaces B …, 2022 - Elsevier
Tumour-targeted near-infrared (NIR) optical imaging is an emerging tool for the detection of
malignant tissues. This modality can be useful in both diagnosis and intraoperative …

Synthesis, 123I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their …

LA Hasnowo, MS Larkina, E Plotnikov… - International Journal of …, 2023 - mdpi.com
Prostate-specific membrane antigen (PSMA) has been identified as a target for the
development of theranostic agents. In our current work, we describe the design and …

Synthesis and Preclinical Evaluation of Small-Molecule Prostate-Specific Membrane Antigen-Targeted Abiraterone Conjugate

AE Machulkin, EA Nimenko, NU Zyk, AA Uspenskaia… - Molecules, 2022 - mdpi.com
Prostate cancer is the second most common type of cancer among men. The main method of
its treatment is androgen deprivation therapy, which has a wide range of side effects. One of …

A cell-impermeable luminogenic probe for near-infrared imaging of prostate-specific membrane antigen in prostate cancer microenvironments

X Yang, SC Nao, C Lin, L Kong, J Wang, CN Ko… - European Journal of …, 2023 - Elsevier
Prostate-specific membrane antigen (PSMA) imaging probes are a promising tool for the
diagnosis and image-guided surgery of prostate cancer (PCa). However, PSMA-specific …