[HTML][HTML] Recent developments in the isolation, biological function, biosynthesis, and synthesis of phenazine natural products

N Guttenberger, W Blankenfeldt… - Bioorganic & medicinal …, 2017 - Elsevier
Phenazines are natural products which are produced by bacteria or by archaeal
Methanosarcina species. The tricyclic ring system enables redox processes, which …

[HTML][HTML] Recent advances in malaria drug discovery

MA Biamonte, J Wanner, KG Le Roch - Bioorganic & medicinal chemistry …, 2013 - Elsevier
This digest covers some of the most relevant progress in malaria drug discovery published
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …

Regio‐and enantioselective photodimerization within the confined space of a homochiral ruthenium/palladium heterometallic coordination cage

J Guo, YW Xu, K Li, LM Xiao, S Chen, K Wu… - Angewandte …, 2017 - Wiley Online Library
The photoinduced regio‐and enantioselective coupling of naphthols and derivatives thereof
is achieved in the confined chiral coordination space of a RuII metalloligand based cage …

Current scenario of artemisinin and its analogues for antimalarial activity

A Kumari, M Karnatak, D Singh, R Shankar… - European journal of …, 2019 - Elsevier
Human malaria, one of the most striking, reemerging infectious diseases, is caused by
several types of Plasmodium parasites. Whilst advances have been made in lowering the …

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones

EN da Silva Júnior, GAM Jardim, C Jacob… - European Journal of …, 2019 - Elsevier
Naphthoquinones are of key importance in organic synthesis and medicinal chemistry. In the
last few years, various synthetic routes have been developed to prepare bioactive …

Sulfur‐Catalyzed Oxidative Condensation of Aryl Alkyl Ketones with o‐Phenylenediamines: Access to Quinoxalines

LA Nguyen, TTT Nguyen, QA Ngo… - Advanced Synthesis & …, 2022 - Wiley Online Library
While elemental sulfur has been largely used as oxidant or sulfurating agent, its role as a
catalyst has not been developed. We report here its catalytic activity in the oxidative …

Synthesis of quinoidal molecules: strategies towards bioactive compounds with an emphasis on lapachones

SL de Castro, FS Emery, EN da Silva Junior - European journal of …, 2013 - Elsevier
Naphthoquinoidal compounds are of great interest in medicinal chemistry. In recent years,
several synthetic routes have been developed to obtain bioactive molecules derived from …

An overview on the antimalarial activity of 1, 2, 4‐trioxanes, 1, 2, 4‐trioxolanes and 1, 2, 4, 5‐tetraoxanes

M Shukla, K Rathi, M Hassam… - Medicinal Research …, 2024 - Wiley Online Library
The demand for novel, fast‐acting, and effective antimalarial medications is increasing
exponentially. Multidrug resistant forms of malarial parasites, which are rapidly spreading …

Dual drug loaded PLGA nanospheres for synergistic efficacy in breast cancer therapy

MS Deepika, R Thangam, TS Sheena… - Materials Science and …, 2019 - Elsevier
Improved therapeutic effects can be achieved by the delivery of combination of drugs
through multifunctional cell targeted nanocarrier systems. The present investigation reports …

Artemisinin‐derived antimalarial endoperoxides from bench‐side to bed‐side: chronological advancements and future challenges

MK Tiwari, S Chaudhary - Medicinal Research Reviews, 2020 - Wiley Online Library
Abstract According to WHO World Malaria Report (2018), nearly 219 million new cases of
malaria occurred and a total no. of 435 000 people died in 2017 due to this infectious …