Bid is an abundant pro-apoptotic protein of the Bcl-2 family that is crucial for death receptor-
mediated apoptosis in many cell systems. Bid action has been proposed to involve the …

Abstract During apoptosis, the BCL‐2‐family protein tBID promotes mitochondrial
permeabilization by activating BAX and BAK and by blocking anti‐apoptotic BCL‐2 …

Aquaporin 3 (AQP3) is an aquaglyceroporin that transports water and glycerol and is
expressed in the epidermis, among other epithelial tissues. We have recently shown that …

Bcl-2 family proteins regulate the release of proteins like cytochrome c from mitochondria
during apoptosis. We used cell-free systems and ultimately a vesicular reconstitution from …

BCL-2 homology 3 (BH3)-only proteins of the BCL-2 family such as tBID and BIM EL assist
BAX-type proteins to breach the permeability barrier of the outer mitochondrial membrane …

Recently, we discovered that Humanin (HN), a small endogenous peptide of 24 amino
acids, binds to and inhibits the proapoptotic protein Bax. We show here that HN also …

The apoptotic protein tBid is effective in promoting both leakage and lipid mixing in
liposomes composed of cardiolipin and phosphatidylcholine at a molar ratio of 1: 2 in the …

Release of cytochrome c from the mitochondrial intermembrane space is critical to apoptosis
induced by a variety of death stimuli. Bid is a BH3-only prodeath Bcl-2 family protein that can …

Apoptosis is an intricately regulated process required for the health and homeostasis of
living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro …

The Bcl-2 homology (BH) 3-only pro-apoptotic Bcl-2 family protein Bim plays an essential
role in the mitochondrial pathway of apoptosis through activation of the BH1–3 multidomain …