d-Amino acids: new clinical pathways for brain diseases

IN de Oliveira Souza, R Roychaudhuri… - Trends in Molecular …, 2023 - cell.com
Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …

Rational and translational implications of D-amino acids for treatment-resistant schizophrenia: from neurobiology to the clinics

A de Bartolomeis, L Vellucci, MC Austin, G De Simone… - Biomolecules, 2022 - mdpi.com
Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …

Co-exposure of butyl benzyl phthalate and TiO2 nanomaterials (anatase) in Metaphire guillelmi: Gut health implications by transcriptomics

X Yang, J Xu, X Chen, M Yao, M Pei, Y Yang… - Journal of …, 2024 - Elsevier
During the COVID-19 pandemic, an abundance of plastic face masks has been consumed
and disposed of in the environment. In addition, substantial amounts of plastic mulch film …

Dysfunctional peroxisomal lipid metabolisms and their ocular manifestations

CT Chen, Z Shao, Z Fu - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Retina is rich in lipids and dyslipidemia causes retinal dysfunction and eye diseases. In
retina, lipids are not only important membrane component in cells and organelles but also …

Discover boy specific-biomarkers and reveal gender-related metabolic differences in central precocious puberty

J Wu, L Wen, J Chen, Y Chang, R Huang, Y Lin… - The Journal of Steroid …, 2023 - Elsevier
The incidence of central precocious puberty (CPP) in boys is rising, but lack of effective
molecular biomarkers often leads to delayed treatment and thus the terrible clinical …

On the regulation of human D‐aspartate oxidase

V Rabattoni, Z Motta, M Miceli, G Molla… - Protein …, 2023 - Wiley Online Library
The human flavoenzyme D‐aspartate oxidase (hDASPO) controls the level of D‐aspartate in
the brain, a molecule acting as an agonist of NMDA receptors and modulator of AMPA and …

Chiral amino acid profiling in serum reveals potential biomarkers for Alzheimer's disease

M Liu, M Li, J He, Y He, J Yang… - Journal of Alzheimer's …, 2023 - content.iospress.com
Background: Alzheimer's disease (AD) is a complex neurodegenerative disease, and
increasing evidence has linked dysregulation of amino acids to AD pathogenesis. However …

Amino Acid Chirality: Stereospecific Conversion and Physiological Implications

K Das, H Balaram, K Sanyal - ACS omega, 2024 - ACS Publications
The absolute configuration dictates the biological role of chiral molecules in the living world.
This is best exemplified by all ribosomally synthesized polypeptides having chiral amino …

Decreased free D-aspartate levels in the blood serum of patients with schizophrenia

M Garofalo, G De Simone, Z Motta, T Nuzzo… - Frontiers in …, 2024 - frontiersin.org
Introduction Schizophrenia (SCZ) and autism spectrum disorder (ASD) are
neurodevelopmental diseases characterized by different psychopathological manifestations …

Genetic variants in DDO and PEX5L in peroxisome‐related pathways predict non‐small cell lung cancer survival

AS Chen, H Liu, Y Wu, S Luo, EF Patz Jr… - Molecular …, 2022 - Wiley Online Library
Peroxisomes play a role in lipid metabolism and regulation of reactive oxygen species, but
its role in development and progression of non‐small cell lung cancer (NSCLC) is not well …