An increasing number of studies show how changes in intracellular metabolic pathways
alter tumor and immune cell function. However, little information about metabolic changes in …

Swelling and the progressive destruction of articular cartilage are major characteristics of
rheumatoid arthritis (RA), a systemic autoimmune disease that directly affects the synovial …

Chemokines are pivotal players in instigation and perpetuation of synovitis through
leukocytes egress from the blood circulation into the inflamed articulation. Multitudinous …

The invasive properties of fibroblast-like synoviocytes (FLS) correlate with radiographic and
histologic damage in rheumatoid arthritis (RA) and pristane-induced arthritis (PIA). We …

The concept that viral sensing systems, via their ability to drive pro-inflammatory cytokine
and interferon production, contribute to the development of autoimmune and …

Objective CXCL10 is expressed in increased levels in highly invasive fibroblast‐like
synoviocytes (FLS) from arthritic DA rats and from patients with rheumatoid arthritis (RA) …

Innate immune detection and subsequent immune responses rely on the initial recognition
of pathogen specific molecular motifs. Foreign nucleic acids are key structures recognised …

Little is known about the regulation of arthritis severity and joint damage in rheumatoid
arthritis (RA). Fibroblast-like synoviocytes (FLS) have a central role in joint damage and …

Osteoarthritis (OA) is a widespread disease that continues to lack approved and efficacious
treatments that modify disease progression. Micronized dehydrated human amnion/chorion …

Fibroblast-like synoviocytes (FLS) play important roles in the pathogenesis of rheumatoid
arthritis (RA). Potassium channels have regulatory roles in many cell functions. We have …