Elucidating the details of the formation, stability, interactions, and reactivity of biomolecular
systems under extreme environmental conditions, including high salt concentrations in …

Understanding molecular mechanisms underlying the complexity of allosteric regulation in
proteins has attracted considerable attention in drug discovery due to the benefits and …

Aberrant activation of Ras GTPase is closely associated with human cancers. Mechanistic
and structural insights into conformational transitions underlying the Ras deactivation …

Since its discovery as an oncogene more than 40 years ago, Ras has been and still is in the
focus of many academic and pharmaceutical labs around the world. A huge amount of work …

Allosteric regulation is a common mechanism employed by complex biomolecular systems
for regulation of activity and adaptability in the cellular environment, serving as an effective …

KRAS is the most frequently mutated RAS protein in cancer patients, and it is estimated that
about 20% of the cancer patients in the United States carried mutant RAS proteins. To …

The last five years have witnessed major developments in the understanding of the allosteric
phenomenon, broadly defined as coupling between remote molecular sites. Such advances …

Localized dynamics of RAS, including regions distal to the nucleotide-binding site, is of high
interest for elucidating the mechanisms by which RAS proteins interact with effectors and …

Biomacromolecules often undergo significant conformational rearrangements during
function. In proteins, these motions typically consist in nontrivial, concerted rearrangement of …

In this work, we experimentally investigate the allosteric transitions between conformational
states on the Ras oncogene protein using high pressure crystallography. Ras protein is a …