Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family
A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of …

Integrin αvβ3 is generously expressed by cancer cells and rapidly dividing endothelial cells.
The principal ligands of the integrin are extracellular matrix proteins, but we have described …

Parathyroid carcinoma (PaC) is a rare cause of primary hyperparathyroidism. Though the
loss of the oncosuppressor CDC73/HRPT2 gene product, parafibromin, has been involved …

Thyroid hormones (TH) are critical regulators of several physiological processes, which
include development, differentiation and growth in virtually all tissues. In past decades …

The metazoan-specific POU domain transcription factor family comprises activities
underpinning developmental processes such as embryonic pluripotency and neuronal …

Background Exercise training protects against heart failure. However, the mechanism
underlying the protective effect of exercise training on angiotensin II (Ang II)-induced cardiac …

Background Thyroid cancer is the most common malignancy of endocrine system, and
papillary thyroid cancer (PTC) is the most common subtype. E2F8, a novel identified E2F …

Background: Long-term management of intermediate-and high-risk differentiated thyroid
cancer (DTC) involves thyrotropin (TSH) suppression with thyroid hormone to prevent …

Since BRCA1 associated breast cancers are frequently classified as hormone receptor
negative or even triple negative, the application of endocrine therapies is rather limited in …

Importance Suppression of thyrotropin (often referred to asthyroid-stimulating hormone,
orTSH) with levothyroxine used in management of intermediate-and high-risk differentiated …