Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …

Abstract Immune-checkpoint-inhibitor (ICI)–associated myotoxicity involves the heart
(myocarditis) and skeletal muscles (myositis), which frequently occur concurrently and are …

Inflammatory dermatosis is characterized by persistent inflammatory infiltration and hard
repair of diseased skin. As a member of the human innate immune cells, macrophages …

Macrophages are innate immune cells in the organism and can be found in almost tissues
and organs. They are highly plastic and heterogeneous cells and can participate in the …

Objectives To examine the effectiveness of Janus-kinase inhibitors (JAKis) or abatacept
(ABA) in patients with rheumatoid arthritis-interstitial lung disease (RA-ILD). Methods …

Through their potential pro-fibrotic and pro-inflammatory properties, macrophages are at the
cross-road of key SSc pathogenic processes and associated manifestations. Investigative …

Abstract Background Systemic sclerosis (SSc) is a systemic autoimmune disease with
heterogeneous clinical presentation and prognosis. JAK inhibitors reduced cutaneous and …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with M1-type
macrophage activation. Mesenchymal stem cells (MSCs) therapies have shown promise in …

Pulmonary fibrosis, a serious complication of systemic lupus erythematosus (SLE) and
coronavirus disease 2019 (COVID-19), leads to irreversible lung damage. However, the …