Drug discovery is a risky, costly and time-consuming process depending on multidisciplinary
methods to create safe and effective medicines. Although considerable progress has been …

Background: The complexity of diseases has led to recent interest in polypharmacology,
which suggests that many effective drugs specially modulate multiple targets. Drugs with …

Drug repositioning has received increased attention since the past decade as several
blockbuster drugs have come out of repositioning. Computational approaches are …

Alzheimer's disease (AD) is a polygenic multifactorial neurodegenerative disease that, after
decades of research and development, is still without a cure. There are some symptomatic …

Drug repurposing (aka drug repositioning) is the search for new indications or molecular
targets distinct from a drug's putative activity, pharmacological effect or binding specificities …

Diabetic retinopathy was included by the World Health Organization in the eye disease
priority list. Up to now, only proliferative diabetic retinopathy can be treated with approved …

Drug combination is a powerful and promising approach for complex disease therapy such
as cancer and cardiovascular disease. However, the number of synergistic drug …

Thymus regenerative therapy implementation is severely obstructed by the limited number
and expansion capacity in vitro of tissue-specific thymic epithelial stem cells (TESC). Current …

Integromics is necessitated as the complex diseases require to collate the integrated
analysis expression, variation, and regulation of genes involved in trigger, prognosis, and …

Synergistic drug combinations play an important role in the treatment of complex diseases.
The identification of effective drug combination is vital to further reduce the side effects and …