Corneal nerves in health and disease

MA Al-Aqaba, VK Dhillon, I Mohammed… - Progress in retinal and …, 2019 - Elsevier
The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …

Growth factor delivery: Defining the next generation platforms for tissue engineering

LMC Aguilar, SM Silva, SE Moulton - Journal of controlled Release, 2019 - Elsevier
Growth factors play a crucial role in tissue engineering by directing the fate of cells and
allowing the formation of tissues. Understanding the key requirements for growth factor …

[HTML][HTML] Topical recombinant human nerve growth factor (cenegermin) for neurotrophic keratopathy: a multicenter randomized vehicle-controlled pivotal trial

SC Pflugfelder, M Massaro-Giordano, VL Perez… - Ophthalmology, 2020 - Elsevier
Purpose To evaluate the efficacy and safety of topical cenegermin (recombinant human
nerve growth factor) in patients with neurotrophic keratopathy. Design Multicenter …

Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials

J Houlton, N Abumaria, SFR Hinkley… - Frontiers in …, 2019 - frontiersin.org
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …

[HTML][HTML] Persistent corneal epithelial defects: a review article

U Vaidyanathan, GC Hopping, HY Liu… - … and Innovation in …, 2019 - ncbi.nlm.nih.gov
Persistent corneal epithelial defects (PEDs or PCEDs) result from the failure of rapid re-
epithelialization and closure within 10-14 days after a corneal injury, even with standard …

Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation

M Wu, LJ Hill, LE Downie, HR Chinnery - Progress in Retinal and Eye …, 2022 - Elsevier
In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

Neuroprotective factors of the retina and their role in promoting survival of retinal ganglion cells: a review

E Fudalej, M Justyniarska, K Kasarełło… - Ophthalmic …, 2021 - karger.com
Retinal ganglion cells (RGCs) play a crucial role in the visual pathway. As their axons form
the optic nerve, apoptosis of these cells causes neurodegenerative vision loss. RGC death …

Treatment of non-infectious corneal injury: review of diagnostic agents, therapeutic medications, and future targets

DH Dang, KM Riaz, D Karamichos - Drugs, 2022 - Springer
Corneal injuries can occur secondary to traumatic, chemical, inflammatory, metabolic,
autoimmune, and iatrogenic causes. Ocular infection may frequently occur concurrent to …

Alternative therapies for dry eye disease

R Mittal, S Patel, A Galor - Current opinion in ophthalmology, 2021 - journals.lww.com
Alternative therapies for dry eye disease : Current Opinion in Ophthalmology Alternative
therapies for dry eye disease : Current Opinion in Ophthalmology Log in or Register Subscribe …

Neurotrophic keratitis: frequency, etiologies, clinical management and outcomes

S Saad, Y Abdelmassih, R Saad, D Guindolet… - The ocular …, 2020 - Elsevier
Purpose To determine neurotrophic keratitis (NK) frequency, etiologies and prognostic
factors, and evaluate the outcome of its management. Methods In this retrospective …