Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories

TC Cairns, X Zheng, P Zheng, J Sun, V Meyer - Biotechnology for Biofuels, 2019 - Springer
Filamentous fungi are harnessed as cell factories for the production of a diverse range of
organic acids, proteins, and secondary metabolites. Growth and morphology have critical …

Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints

BJ Sánchez, C Zhang, A Nilsson… - Molecular systems …, 2017 - embopress.org
Genome‐scale metabolic models (GEM s) are widely used to calculate metabolic
phenotypes. They rely on defining a set of constraints, the most common of which is that the …

The Cell Factory Aspergillus Enters the Big Data Era: Opportunities and Challenges for Optimising Product Formation

V Meyer, M Fiedler, B Nitsche, R King - Filaments in bioprocesses, 2015 - Springer
<? xm-replace_text {Heading}?> Abstract Living with limits. Getting more from less.
Producing commodities and high-value products from renewable resources including waste …

Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

JM Gutierrez, A Feizi, S Li, TB Kallehauge… - Nature …, 2020 - nature.com
Abstract In mammalian cells,> 25% of synthesized proteins are exported through the
secretory pathway. The pathway complexity, however, obfuscates its impact on the secretion …

Edible mycelium bioengineered for enhanced nutritional value and sensory appeal using a modular synthetic biology toolkit

V Maini Rekdal, CRB van der Luijt, Y Chen… - Nature …, 2024 - nature.com
Filamentous fungi are critical in the transition to a more sustainable food system. While
genetic modification of these organisms has promise for enhancing the nutritional value …

Interactions between water activity and temperature on the Aspergillus flavus transcriptome and aflatoxin B1 production

A Medina, MK Gilbert, BM Mack, GR OBrian… - International journal of …, 2017 - Elsevier
Abstract Effects of Aspergillus flavus colonization of maize kernels under different water
activities (aw; 0.99 and 0.91) and temperatures (30, 37° C) on (a) aflatoxin B 1 (AFB 1) …

Membrane Traffic in Aspergillus oryzae and Related Filamentous Fungi

Y Higuchi - Journal of Fungi, 2021 - mdpi.com
The industrially important filamentous fungus Aspergillus oryzae, known as the yellow Koji
mold and also designated the Japanese National fungus, has been investigated for …

Filamentous fungi-like secretory pathway strayed in a yeast system: peculiarities of Yarrowia lipolytica secretory pathway underlying its extraordinary performance

E Celińska, JM Nicaud - Applied microbiology and biotechnology, 2019 - Springer
Microbial production of secretory proteins constitutes one of the key branches of current
industrial biotechnology, earning billion dollar (USD) revenues each year. That industrial …

Expression and characterization of camel chymosin in Pichia pastoris

N Wang, KY Wang, GQ Li, WF Guo, DH Liu - Protein expression and …, 2015 - Elsevier
Chymosin efficiently coagulates milk and so is widely used in commercial cheese
production. Traditional chymosin production requires the slaughter of a large numbers of …

Harnessing the knowledge of protein secretion for enhanced protein production in filamentous fungi

X Sun, X Su - World Journal of Microbiology and Biotechnology, 2019 - Springer
Filamentous fungi are important microorganisms used in industrial production of proteins
and enzymes. Among these organisms, Trichoderma reesei, Aspergilli, and more recently …