Amino acid transporters revisited: New views in health and disease
P Kandasamy, G Gyimesi, Y Kanai… - Trends in biochemical …, 2018 - cell.com
Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …
Astrogliosis
MV Sofroniew - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
In addition to their many functions in the healthy central nervous system (CNS), astrocytes
respond to CNS damage and disease through a process called astrogliosis. For many …
respond to CNS damage and disease through a process called astrogliosis. For many …
[HTML][HTML] Glutamate as a neurotransmitter in the healthy brain
Y Zhou, NC Danbolt - Journal of neural transmission, 2014 - Springer
Glutamate is the most abundant free amino acid in the brain and is at the crossroad between
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …
[HTML][HTML] Astrocytes: biology and pathology
MV Sofroniew, HV Vinters - Acta neuropathologica, 2010 - Springer
Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They
contiguously tile the entire central nervous system (CNS) and exert many essential complex …
contiguously tile the entire central nervous system (CNS) and exert many essential complex …
Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: Opportunities for novel therapeutics development
JL Green, WF Dos Santos, ACK Fontana - Biochemical pharmacology, 2021 - Elsevier
Epilepsy is a complex neurological syndrome characterized by seizures resulting from
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …
Molecular dissection of reactive astrogliosis and glial scar formation
MV Sofroniew - Trends in neurosciences, 2009 - cell.com
Reactive astrogliosis, whereby astrocytes undergo varying molecular and morphological
changes, is a ubiquitous but poorly understood hallmark of all central nervous system …
changes, is a ubiquitous but poorly understood hallmark of all central nervous system …
[HTML][HTML] Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury
Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide.
Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain …
Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain …
Mechanisms of glutamate transport
RJ Vandenberg, RM Ryan - Physiological reviews, 2013 - journals.physiology.org
l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …
nervous system and plays important roles in a wide variety of brain functions, but it is also a …
[HTML][HTML] GABA and glutamate transporters in brain
Y Zhou, NC Danbolt - Frontiers in endocrinology, 2013 - frontiersin.org
The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1;
GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes …
GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes …
[HTML][HTML] Reactive astrocytes as therapeutic targets for CNS disorders
ME Hamby, MV Sofroniew - Neurotherapeutics, 2010 - Elsevier
Reactive astrogliosis has long been recognized as a ubiquitous feature of CNS pathologies.
Although its roles in CNS pathology are only beginning to be defined, genetic tools are …
Although its roles in CNS pathology are only beginning to be defined, genetic tools are …