Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone
formation and resorption. The balance between the two phases is crucial for sustaining bone …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density
diminishing, and degeneration of bone microstructure, which is accompanied by a tendency …

Rheumatoid arthritis (RA) is an inflammatory disease characterized by a variety of symptoms
and pathologies often presenting with polyarthritis. The primary symptom in the initial stage …

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health.
Circulating adiponectin increases in lean states such as caloric restriction (CR), but the …

Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

Wnt signaling and its bone tissue–specific inhibitor sclerostin are key regulators of bone
homeostasis. The therapeutic potential of anti-sclerostin antibodies (Scl-Abs), for bone mass …