Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium (III) in cell-free media
J Malina, O Novakova, BK Keppler, E Alessio… - JBIC Journal of …, 2001 - Springer
Modifications of natural DNA by three anticancer heterocyclic ruthenium (III) compounds
were studied by methods of molecular biophysics. These methods included DNA binding …
were studied by methods of molecular biophysics. These methods included DNA binding …
DNA–protein cross‐linking by trans ‐[PtCl 2 ( E‐ iminoether) 2 ]. A concept for activation of the trans …
O Novakova, J Kasparkova, J Malina… - Nucleic acids …, 2003 - academic.oup.com
The structure–pharmacological activity relationships generally accepted for antitumor
platinum compounds stressed the necessity for the cis‐[PtX 2 (amine) 2] structure while the …
platinum compounds stressed the necessity for the cis‐[PtX 2 (amine) 2] structure while the …
Cytotoxicity, apoptosis, and in vitro DNA damage induced by potassium chromate
A Flores, JM Pérez - Toxicology and applied pharmacology, 1999 - Elsevier
Cr6+ is a known human cytotoxic and carcinogenic agent that requires intracellular
reduction for activation. We have analyzed the cytotoxic and DNA binding properties of …
reduction for activation. We have analyzed the cytotoxic and DNA binding properties of …
trans-Platinum Compounds in Cancer Therapy: A Largely Unexplored Strategy for Identifying Novel Antitumor Platinum Drugs
G Natile, M Coluccia - Metallopharmaceuticals I: DNA Interactions, 1999 - Springer
In recent years, several exceptions to the rule that the presence of two good leaving groups
in cis positions of platinum complexes is a necessary condition for their antitumor activity …
in cis positions of platinum complexes is a necessary condition for their antitumor activity …
Synthesis, characterization and binding studies of chromium (III) complex containing an intercalating ligand with DNA
VG Vaidyanathan, BU Nair - Journal of inorganic biochemistry, 2003 - Elsevier
A chromium (III) complex [Cr (DPPZ) 2Cl2]+, where DPPZ is a planar bidentate ligand with
an extended aromatic system, has been found to bind strongly to CT DNA with an apparent …
an extended aromatic system, has been found to bind strongly to CT DNA with an apparent …
B− Z Conformational Transition of DNA Monitored by Vibrational Circular Dichroism. Ab Initio Interpretation of the Experiment
V Andrushchenko, H Wieser, P Bouř - The Journal of Physical …, 2002 - ACS Publications
The B− Z conformational transition was induced by Mn2+ ions in a synthetic oligonucleotide
(dG-dC) 20 and monitored by the vibrational circular dichroism (VCD). For the first time, the …
(dG-dC) 20 and monitored by the vibrational circular dichroism (VCD). For the first time, the …
[HTML][HTML] The study of naphthoquinones and their complexes with DNA by using Raman spectroscopy and surface enhanced Raman spectroscopy: new insight into …
V Vaverkova, O Vrana, V Adam, T Pekarek… - BioMed Research …, 2014 - hindawi.com
Naphthoquinones represent the group of plant secondary metabolites with cytotoxic
properties based on their ability to generate reactive oxygen species and interfere with the …
properties based on their ability to generate reactive oxygen species and interfere with the …
X-ray Structure of Cytotoxic trans-[PtCl2(dimethylamine)(isopropylamine)]: Interstrand Cross-Link Efficiency, DNA Sequence Specificity, and Inhibition of the B−Z …
JM Pérez, EI Montero, AM González… - Journal of medicinal …, 2000 - ACS Publications
We report here the X-ray structure of cytotoxic trans-[PtCl2 (dimethylamine)(isopropylamine)]
. This trans-platinum compound crystallizes in the monoclinic system, with Z= 8, in the spatial …
. This trans-platinum compound crystallizes in the monoclinic system, with Z= 8, in the spatial …
DNA interactions of new antitumor aminophosphine platinum (II) complexes
K Neplechová, J Kašpárková, O Vrána… - Molecular …, 1999 - ASPET
Mechanistic studies are presented of a novel class of aminophosphine platinum (II)
complexes as potential anticancer agents. These new agents, which have demonstrated …
complexes as potential anticancer agents. These new agents, which have demonstrated …
X-ray Structures of the First Platinum Complexes with Z Configuration Iminoether Ligands: trans-Dichlorobis (1-imino-1-methoxy-2, 2 '-dimethylpropane) platinum (II) …
AM Gonzalez, R Cini, FP Intini, C Pacifico… - Inorganic …, 2002 - ACS Publications
Platinum complexes with Z configuration iminoether ligands (trans-[PtCl2 {HN C (OMe) Bu t}
2], 1, and trans-[PtCl4 {HN C (OMe) Bu t} 2], 2) have been structurally characterized for the …
2], 1, and trans-[PtCl4 {HN C (OMe) Bu t} 2], 2) have been structurally characterized for the …