[HTML][HTML] Mapping inherited genetic variation with opposite effects on autoimmune disease and cancer identifies candidate drug targets associated with the anti-tumor …

J Chen, MP Epstein, JM Schildkraut, SP Kar - medRxiv, 2023 - ncbi.nlm.nih.gov
Background Germline alleles near genes that encode certain immune checkpoints (CTLA4,
CD200) are associated with autoimmune/autoinflammatory disease and cancer but in …

Genetic association and machine learning improves discovery and prediction of type 1 diabetes

C McGrail, TJ Sears, P Kudtarkar, H Carter… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Type 1 diabetes (T1D) has a large genetic component, and expanded genetic studies of
T1D can lead to novel biological and therapeutic discovery and improved risk prediction. In …