Cancers develop due to the accumulation of genetic and epigenetic alterations. Genetic
alterations are induced by aging, mutagenic chemicals, ultraviolet light, and other factors; …

Sažetak Estrogens have long been known as important regulators of the female
reproductive functions; however, our understanding of the role estrogens play in the human …

Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in
cancer studies. However, little is known about the transcriptomic profile of NAT, how it is …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

Previous observations have demonstrated that embryonic exposure to the endocrine
disruptor vinclozolin during gonadal sex determination promotes transgenerational adult …

DNA methylation is an indispensible epigenetic modification required for regulating the
expression of mammalian genomes. Immunoprecipitation-based methods for DNA …

Early-life adversity is associated with a broad scope of life-long health and behavioral
disorders. Particularly critical is the role of the mother. A possible mechanism is that these …

Breast cancer affects one in seven women worldwide during their lifetime. Widespread
mammographic screening programs and education campaigns allow for early detection of …

Invasiveness underlies cancer aggressiveness and is a hallmark of malignancy. Most
malignant tumors have elevated levels of Tn, an O-GalNAc glycan. Mechanisms underlying …