The current literature is devoid of a clearcut definition of mitotic catastrophe, a type of cell
death that occurs during mitosis. Here, we propose that mitotic catastrophe results from a …

CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …

Accumulation of amyloid-β (Aβ) and Tau is an invariant feature of Alzheimer disease (AD).
The upstream role of Aβ accumulation in the disease pathogenesis is widely accepted, and …

Understanding molecular mechanisms mediating epileptogenesis is critical for developing
more effective therapies for epilepsy. We recently found that the mammalian target of …

Throughout the process of pathogen–host co-evolution, viruses have developed a battery of
distinct strategies to overcome biochemical and immunological defenses of the host. Thus …

Autophagic cell death is morphologically characterized by an accumulation of autophagic
vacuoles. Here, we show that inactivation of LAMP2 by RNA interference or by homologous …

Hydroxychloroquine (HCQ) is a lysosomotropic amine with cytotoxic properties. Here, we
show that HCQ induces signs of lysosomal membrane permeabilization (LMP), such as the …

The cyclin-dependent kinase 1 (Cdk1), formerly called Cdc2 (or p34 Cdc2), interacts with
cyclin B1 to form an active heterodimer. The activity of Cdk1 is subjected to a complex …

Rapamycin (RAPA) is a potent immunosuppressive macrolide hitherto believed to mediate
its action primarily via suppression of lymphocyte responses to interleukin 2 (IL-2) and other …

Dendritic cells (DCs) in mucosal surfaces are early targets for human immunodeficiency
virus-1 (HIV-1). DCs mount rapid and robust immune responses upon pathogen encounter …