Brain metastases are a very common manifestation of cancer that have historically been
approached as a single disease entity given the uniform association with poor clinical …

PURPOSE Conventional wisdom has rendered patients with brain metastases ineligible for
clinical trials for fear that poor survival could mask the benefit of otherwise promising …

The incidence of brain metastasis is increasing as improvements in systemic therapy lead to
increased survival. This provides new and challenging clinical decisions for patients who …

Background Prognostic estimates for patients with brain metastases (BM) stem from
younger, healthier patients enrolled in clinical trials or databases from academic centers. We …

Abstract The Graded Prognostic Assessment (GPA) score has the best accuracy among
prognostic scales for patients with brain metastases (BM). A wide range of GPA-derived …

BACKGROUND: There are limited data regarding outcomes for patients with gastrointestinal
(GI) primaries and brain metastases treated with stereotactic radiosurgery (SRS) …

The standard clinical approach to assess the radiotherapy outcome in brain metastasis is
through monitoring the changes in tumour size on longitudinal MRI. This assessment …

Purpose The incidence of intracranial metastatic disease (IMD) in patients with
gastrointestinal (GI) cancers is rising. Expression of the erythroblastic oncogene B-2 …

Background Surgical resection of brain metastases (BM) improves overall survival (OS) in
selected patients. Selecting those patients likely to benefit from surgery is challenging. The …

OBJECTIVE The goal of this study was to characterize local tumor control (LC), overall
survival (OS), and safety of stereotactic radiosurgery for colorectal brain metastasis (CRBM) …